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The protein encoded by FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. Additionally we are shipping FXR1 Proteins (4) and many more products for this protein.
Showing 10 out of 81 products:
Mouse (Murine) Polyclonal FXR1 Primary Antibody for WB - ABIN1881357
Coffee, Tessier, Woodruff, Broadie: Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. in Disease models & mechanisms 2010
Show all 5 references for ABIN1881357
Chicken Polyclonal FXR1 Primary Antibody for WB - ABIN2778725
Blonden, van t Padje, Severijnen, Destree, Oostra, Willemsen: Two members of the Fxr gene family, Fmr1 and Fxr1, are differentially expressed in Xenopus tropicalis. in The International journal of developmental biology 2005
Dog (Canine) Polyclonal FXR1 Primary Antibody for WB - ABIN782994
Coon, Matsunami, Stevens, Miller, Pingree, Camp, Thomas, Krasny, Lainhart, Leppert, McMahon: Evidence for linkage on chromosome 3q25-27 in a large autism extended pedigree. in Human heredity 2006
FXR1P is a GSK3beta (show GSK3b Antibodies) substrate with a role in regulating mood and emotion processing
Removal of FXR1P from the forebrain of postnatal mice selectively enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP (show SCP2 Antibodies)), and de novo GluA2 (show GRIA2 Antibodies) synthesis.
FXR1P was highly expressed during hippocampal development and co-localized with ribosomes and mRNAs in the dendrite and at a subset of spines.
FXR1P is required for efficient processing of pre-microR-9 and pre-microR-124 in vitro and forms a complex with Dicer (show DICER1 Antibodies) and pre-miRNAs.
Fxr1 knockout hearts exhibit an up-regulation of desmoplakin (show DSP Antibodies) and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
Targeting the p38 mitogen-activated protein kinase (show MAPK14 Antibodies) pathway of LPS (show TLR4 Antibodies)-treated cells with small molecule inhibitors can induce FXR1 protein expression.
Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa are widely distributed in mouse organs, while in striated (show NSDHL Antibodies) muscles these isoforms are replaced by proteins of 82 and 84 kDa containing an extra pocket of 27 amino acids.
FXR1P operates as a repressor of TNF (show TNF Antibodies) translation
the data clearly demonstrate the importance of FXR1P RBP (show RBP4 Antibodies) in the regulation of a wide spectrum of inflammatory genes and suggest an important role of MAP signalling in the response of macrophages to selected TLR ligands, including CpG.
Fxr1 regulates mammalian circadian behavioral rhythms.
Fxr1 plays a vital role during Xenopus embryogenesis. Knockdown of Fxr1 has highly muscle-specific (show EIF3K Antibodies) effects leading to disruption of MyoD (show MYOD1 Antibodies) expression, inhibition of somite myotomal cell rotation and segmentation, and abnormal dermatome formation.
P97 (show EIF4G2 Antibodies) interacts with 3' UTR (show UTS2R Antibodies)-binding FXR1a-associated microRNPs and with PARN (show PARN Antibodies), which binds mRNA 5' caps (show CAPS Antibodies), forming a specialized complex to translate recruited mRNAs in these altered canonical translation conditions.
An accumulation of 8 SNPs in the fragile gene family (FMR1 (show FMR1 Antibodies), FXR1 and FXR2 (show FXR2 Antibodies))were found associated with autistic traits in a sample of male patients.
The mechanisms by which FXR1 executes its regulatory function by forming a novel complex with two other oncogenes, protein kinase C (show PKC Antibodies), iota and epithelial cell transforming 2, located in the same amplicon via distinct binding mechanisms, were identified.
binding of PKP1 (show PKP1 Antibodies)/3 to FXR1 was RNA independent, and both PKP3 (show PKP3 Antibodies) and FXR1 stabilized PKP2 (show PKP2 Antibodies) mRNA.
Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A (show LMNA Antibodies) p.R482W mutation elicits a myogenic gene expression program in preadipocytes.
findings showed that FXR1P interacts with BTF (show BCLAF1 Antibodies) in vivo and proved that FXR1P and BTF (show BCLAF1 Antibodies) can co-localize mainly in the cytoplasm around the nucleus
FXR1 and UPF1 (show UPF1 Antibodies) may have a functional role in prostate cancer progression and metastasis.
Our study describes a novel role of FXR1P that has crucial implications for the understanding of its role during myogenesis and muscle development
Data show that the nuclear localization signals of the FXR1 and FXR2 (show FXR2 Antibodies) comprise tandem Tudor domain architectures.
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
Fragile X mental retardation syndrome-related protein 1 homolog
, fragile X mental retardation syndrome-related protein 1 homolog
, fragile X mental retardation syndrome-related protein 1
, fragile X mental retardation, autosomal homolog 1
, fragile X mental retardation-related protein 1
, fragile X mental retardation syndrome-related protein 1-like
, fragile X mental retardation gene, autosomal homolog
, fragile-X-related protein 1
, fragile X-related protein
, fragile X mental retardation syndrome-related protein 1 homolog A
, fragile X mental retardation gene 1, autosomal homolog