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anti-Fragile X Mental Retardation 1 (FMR1) Antibodies

The protein encoded by FMR1 binds RNA and is associated with polysomes. Additionally we are shipping FMR1 Proteins (6) and FMR1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FMR1 2332 Q06787
FMR1 24948 Q80WE1
FMR1 14265  
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Top anti-FMR1 Antibodies at antibodies-online.com

Showing 10 out of 174 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of FMR1 Antibody (N-term) in mouse lung tissue lysates (35 µg/lane). FMR1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Formalin-fixed and paraffin-embedded human brain tissue reacted with FMR1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of FMR1 Antibody (N-term) (ABIN390866) in mouse lung tissue lysates (35 µg/lane). FMR1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Fruit Fly Mouse Un-conjugated ICC, IF, IP, ELISA, WB 50 μL Log in to see 5 to 6 Days
$402.29
Details
Human Goat Un-conjugated ELISA, IHC (p), WB 0.1 mg Log in to see 5 to 7 Days
$408.19
Details
Rat Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB Western Blot: FMRP Antibody [NBP1-51944] - NBP1-51944 (0.3ug/ml) staining of Kelly lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 5 to 7 Days
$408.19
Details
Human Mouse Un-conjugated IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FMR1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FMR1. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FMR1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FMR1. 100 μL Log in to see 2 to 3 Days
$423.50
Details

FMR1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-FMR1 Antibodies

  1. Fruit Fly (Drosophila melanogaster) Monoclonal FMR1 Primary Antibody for ICC, IF - ABIN108599 : Wan, Dockendorff, Jongens, Dreyfuss: Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. in Molecular and cellular biology 2000 (PubMed)
    Show all 7 references for ABIN108599

  2. Rat (Rattus) Polyclonal FMR1 Primary Antibody for WB - ABIN610747 : Anderson, Teutsch, Dong, Wortis: An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 2 references for ABIN610747

  3. Human Polyclonal FMR1 Primary Antibody for EIA, WB - ABIN452426 : Dölen, Osterweil, Rao, Smith, Auerbach, Chattarji, Bear: Correction of fragile X syndrome in mice. in Neuron 2007 (PubMed)

  4. Human Polyclonal FMR1 Primary Antibody for EIA, WB - ABIN453027 : Yuhas, Walichiewicz, Pan, Zhang, Casillas, Hagerman, Tassone: High-risk fragile x screening in Guatemala: use of a new blood spot polymerase chain reaction technique. in Genetic testing and molecular biomarkers 2009 (PubMed)

More Antibodies against FMR1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.

  2. results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.

  3. results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 (show TARDBP Antibodies) overexpression

  4. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral (show LSM14A Antibodies) in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways

  5. dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.

  6. Driving expression of FMRpolyG enhanced induction of UPS impairment in cell models, while prevention of RAN translation attenuated UPS impairment in cells and suppressed the genetic interaction with UPS manipulation in Dr (show USP14 Antibodies)osophila

  7. These results show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical period development of learning and memory circuitry in the Drosophila brain.

  8. upon the stimulation of replication stress, dFMR1 is associated with chromatin in a domain-specific manner, which is essential for its ability to induce the phosphorylation of H2Av (show H2AFV Antibodies).

  9. FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome.

  10. FMRP negatively regulates HSPG (show SDC2 Antibodies) co-receptors controlling trans-synaptic signaling during synaptogenesis

Human Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. FMR1 Gene Missense SNPs

  2. Data show that CGG repeats within the testes of a fetus carrying a full Fragile X syndrome (FXS) mutation and another fetus carrying mosaicism FXS mutation in fragile X mental retardation 1 protein (FMR1).

  3. Despite increasing use, FMR1 CGG repeats in the normal range cannot be used as a predictor of ovarian response to gonadotrophin stimulation

  4. Results suggest that the skewed X chromosome inactivation of the normal FMR1 allele may be a risk factor for the development of fragile-X-associated tremor/ataxia (show USP14 Antibodies) syndrome

  5. Triplet expansion cytosine-guanine-guanine mutation dynamics of the FMR1 gene were observed in a family with primary ovarian insufficiency and tremor-ataxia (show USP14 Antibodies) syndrome.

  6. Full mutation/deletion FMR1 mosaicism was identified in five males with Fragile X syndrome.

  7. Women who carry an FMR1 (i.e., fragile X) premutation have specific health risks over their lifetime.

  8. Maternal pragmatic language difficulties of mothers with the FMR1 premutation were significantly associated with poorer child receptive vocabulary and expressive syntax skills of their adolescent/young adult sons with fragile X syndrome, with medium effect sizes

  9. Results suggest that dysregulation of FMR1 protein/mammalian target of rapamycin (show FRAP1 Antibodies) pathways can have a role in pathogenesis of encephalopathy of prematurity, as otherwise observed in the most common inherited syndrome of cognitive disability (eg, fragile X syndrome)

  10. We developed one indirect and one direct single-round, single-cell PCR protocols using five highly polymorphic, not previously described, FMR1-linked SSRs

Zebrafish Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar (show ADAR Antibodies) genes and Adar2 (show ADARB1 Antibodies) protein increased in fmr1-/- zebrafish

  2. Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.

Mouse (Murine) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. Study showed that Fmr1 knock-out astrocytes affect the dendritic arborization of all subtypes of hippocampal neurons and that select populations of hippocampal neurons are more effected by this astrocyte-mediated developmental delay; specifically, the stellate neurons grown on Fmr1 knock-out astrocytes exhibit the most pervasive developmental delays

  2. The data reveal an age-dependent deficit in long-term potentiation in Fmr1KO mice, which may correlate to some of the complex age-related deficits in Fragile X syndrome.

  3. increased white matter seen in the FMR1-KO-FVB could be highlighting a structural over-connectivity, which could lead to some of the behavioral abnormalities seen with the FMR1-KO-FVB mice

  4. Study shows deficits in habituation of neural responses to repeated sounds in the Fragile X Mental Retardation gene (Fmr1) KO mice as seen in humans with fragile X syndrome.

  5. we find abnormal patterns of coupling between theta and gamma oscillations in perisomatic and dendritic hippocampal CA1 (show CA1 Antibodies) local field potentials of the Fmr1 knockout mice.

  6. This study demonstrated that in the active phase of the circadian cycle, Fmr1 KO mice are hyperactive, and demonstrate reduced anxiety and impaired learning and memory.

  7. Study reveals a mechanism for the local regulation of translation by miR (show MLXIP Antibodies)-181d and FMRP during axon development.

  8. Results indicate that, while the fragile X (Fmr1) mouse model effectively recapitulates many molecular and cellular aspects of fragile X syndrome, the cognitive profile of Fmr1 mice generally does not recapitulate the primary cognitive deficits in the human syndrome, even when diverse and challenging tasks are imposed.

  9. the absence of fragile X mental retardation protein (show NUFIP2 Antibodies) has divergent effects on the function of individual types of ion channels not only between brain regions

  10. Results of our study suggest that the eIF4E (show EIF4E Antibodies)/Fmr1 double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

FMR1 Antigen Profile

Protein Summary

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Gene names and symbols associated with FMR1

  • CG6203 gene product from transcript CG6203-RC (Fmr1) antibody
  • fragile X mental retardation 1 (FMR1) antibody
  • fragile X mental retardation 1 (Fmr1) antibody
  • fragile X mental retardation 1 (fmr1) antibody
  • fragile X mental retardation syndrome 1 (Fmr1) antibody
  • AT24755 antibody
  • BcDNA:GM08679 antibody
  • cg6203 antibody
  • dfmr antibody
  • dfmr1 antibody
  • dFmrp antibody
  • dfxr antibody
  • dfxr1 antibody
  • dFXRP antibody
  • Dmel\\CG6203 antibody
  • dmfr1 antibody
  • EP(3)3517 antibody
  • fmr antibody
  • Fmr-1 antibody
  • fmr1 antibody
  • Fmrp antibody
  • FRAXA antibody
  • FXR antibody
  • POF antibody
  • POF1 antibody
  • zFMR1 antibody

Protein level used designations for FMR1

CG6203-PA , CG6203-PB , CG6203-PC , CG6203-PD , CG6203-PE , CG6203-PF , CG6203-PG , CG6203-PH , CG6203-PI , Fmr1-PA , Fmr1-PB , Fmr1-PC , Fmr1-PD , Fmr1-PE , Fmr1-PF , Fmr1-PG , Fmr1-PH , Fmr1-PI , Fragile-X mental retardation protein , Fragile-X-related , dFmr1 , drosophila fragile X mental retardation protein , fragile X , fragile X mental retardation , fragile X mental retardation 1 , fragile X mental retardation gene , fragile X mental retardation protein , fragile X protein , fragile X related protein , fragile X-related , fragile x related , fragile-X , fragile X mental retardation protein 1 , fragile X mental retardation protein 1 homolog , fragile X mental retardation syndrome 1 homolog , fragile X mental retardation-1 protein , protein FMR-1 , ragile X mental retardation protein , fragile X mental retardation 1 protein , FMRP , mFmr1p

GENE ID SPECIES
37528 Drosophila melanogaster
465894 Pan troglodytes
2332 Homo sapiens
481070 Canis lupus familiaris
24948 Rattus norvegicus
259191 Danio rerio
422395 Gallus gallus
100155078 Sus scrofa
507482 Bos taurus
100172902 Pongo abelii
14265 Mus musculus
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