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Fras1 Related Extracellular Matrix Protein 2 (FREM2) ELISA Kits

FREM2 encodes a membrane protein that belongs to the FRAS1 family. Additionally we are shipping FREM2 Antibodies (25) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human FREM2 FREM2 341640 Q5SZK8
Anti-Mouse FREM2 FREM2 242022 Q6NVD0
Anti-Rat FREM2 FREM2 310418  
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More ELISA Kits for FREM2 Interaction Partners

Human Fras1 Related Extracellular Matrix Protein 2 (FREM2) interaction partners

  1. In 15 of 590 families, we identified recessive mutations in the genes FRAS1 (show FRAS1 ELISA Kits), FREM2, GRIP1 (show NCOA2 ELISA Kits), FREM1 (show FREM1 ELISA Kits), ITGA8, and GREM1 (show GREM1 ELISA Kits), all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.

  2. Amplification of the FREM2 gene is associated with mesenchymal differentiation in gliosarcoma.

  3. Heterozygous missense mutations in FREM2 cause non-syndromic congenital abnormalities of the kidney and urinary tract in humans.

  4. report on 2 fetuses affected by Fraser syndrome (FS); a homozygous IVS14 + 1G -- A mutation in FREM2 was indentified; present report provides additional evidence that FS may be caused by complete or near-complete lack or loss of function of FREM2 protein

  5. 1 new mutation in FREM2 was identified in families with Fraser syndrome.

Mouse (Murine) Fras1 Related Extracellular Matrix Protein 2 (FREM2) interaction partners

  1. Report Fras1 (show FRAS1 ELISA Kits) up-regulation/Frem down-regulation in nephrons from mice with polycystic kidney disease and Frem2 mutations.

  2. The QBRICK (show FREM1 ELISA Kits), together with Frem2, defines the ability of BMs to bind integrin 81 through modulating the BM assembly of nephronectin (show NPNT ELISA Kits), thereby regulating the integrin 81-mediated signals transmitted from the ureteric buds to the metanephric mesenchyme.

  3. expression of Frem2 may dynamically alter the extracellular matrix to provide a substrate for cell migration and rearrangements during embryogenesis

  4. QBRICK/Frem1 (show FREM1 ELISA Kits), Fras1 (show FRAS1 ELISA Kits), and Frem2 interactions at the basement membrane have roles in preventing Fraser syndrome-like defects

  5. Study reports a comparative analysis of the spatiotemporal localization of Fras1, Frem1, Frem2 and Frem3 proteins during mouse embryonic development.

  6. Fras1 (show FRAS1 ELISA Kits) is not only essential as a component of a macromolecular complex for the extracellular stabilization of Frem2 but it is also required for its proper intracellular trafficking and export from embryonic epithelial cells.

  7. The localization pattern of Fras1 (show FRAS1 ELISA Kits) and Frem2 was indistinguishable, while both proteins along with Frem3 could be detected even in the absence of Frem1 (show FREM1 ELISA Kits).

FREM2 Antigen Profile

Antigen Summary

This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.

Gene names and symbols associated with FREM2

  • FRAS1 related extracellular matrix protein 2 (FREM2) antibody
  • Fras1 related extracellular matrix protein 2 (Frem2) antibody
  • 6030440P17Rik antibody
  • 8430406N05Rik antibody
  • b2b1562Clo antibody
  • Gm409 antibody
  • my antibody
  • ne antibody
  • nv1 antibody
  • RGD1566012 antibody

Protein level used designations for FREM2

ECM3 homolog , FRAS1-related extracellular matrix protein 2 , NV domain containing protein NV1 , NV domain-containing protein 1

GENE ID SPECIES
341640 Homo sapiens
242022 Mus musculus
310418 Rattus norvegicus
486002 Canis lupus familiaris
527601 Bos taurus
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