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Free Fatty Acid Receptor 2 (FFAR2) ELISA Kits

FFAR2 encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. Additionally we are shipping FFAR2 Antibodies (77) and FFAR2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human FFAR2 FFAR2 2867 O15552
Anti-Rat FFAR2 FFAR2 292794 Q76EI6
FFAR2 233079 Q8VCK6
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Top FFAR2 ELISA Kits at antibodies-online.com

Showing 1 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.055 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$757.89
Details

More ELISA Kits for FFAR2 Interaction Partners

Human Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII (show TH ELISA Kits) of FFA2, there are clear differences in how these interactions occur.

  2. FFAR2 signaling occurs by divergent G protein pathways.

  3. GPR3 agonism potentiates insulin secretion in isolated islets.

  4. GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1 (show XBP1 ELISA Kits), while A549 cells overexpressing XBP1 (show XBP1 ELISA Kits) displayed elevated GPR43 levels.

  5. FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis.

  6. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS ELISA Kits) secretion by coupling to Gi-type G proteins.

  7. [review] In vivo and in vitro studies suggest that short-chain fatty acid receptors (SCFAs) stimulate gut (show GUSB ELISA Kits) hormone secretion; therefore, the SCFA-FFA signal is likely to be important for gut (show GUSB ELISA Kits) physiological functions.

  8. GPR43 modulates NF-kappaB (show NFKB1 ELISA Kits) activity via beta-arrestin 2 (show ARRB2 ELISA Kits).

  9. Propionate-stimulated GPR41 (show FFAR3 ELISA Kits) strongly coupled to ERK1/2 (show MAPK1/3 ELISA Kits) activation, while the coupling of linoleic acid-activated GPR40 (show FFAR1 ELISA Kits) and acetate-activated GPR43 was weaker.

  10. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Mouse (Murine) Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. FFAR2 signaling occurs by divergent G protein pathways.

  2. Data (including data from studies in knockout mice) suggest Ffar2 expression in pancreatic beta-cells plays role in gestational glucose homeostasis; this mechanism involves gut microbiome (which contributes to plasma short-chain fatty acid levels).

  3. High fat diet fed GPR43 KO mice develop glucose intolerance due to a defect in insulin (show INS ELISA Kits) secretion, reduced beta-cell mass and expression of differentiation genes. GPR3 (show GPR3 ELISA Kits) agonism potentiates insulin (show INS ELISA Kits) secretion.

  4. GPR-43-deficient mice show a greatly decreased inflammatory reaction to knee injection of monosodium urate crystals in a mouse model of gout.

  5. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS ELISA Kits) secretion by coupling to Gi-type G proteins.

  6. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis.

  7. Data from transgenic mice suggest that Ffar2/Gpr43 and Ffar3/Gpr41 (show FFAR3 ELISA Kits) both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar2/Gpr43 appears to play this role alone in enteric leukocytes and Ffar3/Gpr41 (show FFAR3 ELISA Kits) alone in enteric neurons.

  8. Short-chain fatty acids activate GPR43 and on intestinal epithelial cells, leading to mitogen-activated protein kinase (show MAPK1 ELISA Kits) signaling and rapid production of chemokines and cytokines. These pathways mediate protective immunity and tissue inflammation in mice.

  9. Data suggest that alpha-gustducin (show GNAT3 ELISA Kits) in colonic mucosa is a key signaling molecule coupling free fatty acid receptors (Gpr43, Gpr119 (show GPR119 ELISA Kits), Gpr120 (show O3FAR1 ELISA Kits)) and possibly bile acid receptor (show NR1H4 ELISA Kits) (TGR5 (show GPBAR1 ELISA Kits)) to secretion of GLP-1 (glucagon-like peptide 1 (show GCG ELISA Kits)).

  10. Inulin-type fructans, paradoxically counteract GPR43 overexpression induced in the adipose tissue by an high fat diet.

FFAR2 Antigen Profile

Antigen Summary

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels.

Gene names and symbols associated with FFAR2

  • free fatty acid receptor 2 (FFAR2) antibody
  • free fatty acid receptor 2 (Ffar2) antibody
  • FFA2R antibody
  • GPCR43 antibody
  • Gpr43 antibody

Protein level used designations for FFAR2

G protein-coupled receptor 43 , G-protein coupled receptor 43 , free fatty acid activated receptor 2 , leukocyte-specific STAT-induced GPCR

GENE ID SPECIES
2867 Homo sapiens
292794 Rattus norvegicus
233079 Mus musculus
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