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Free Fatty Acid Receptor 2 Proteins (FFAR2)

FFAR2 encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. Additionally we are shipping FFAR2 Antibodies (77) and FFAR2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FFAR2 2867 O15552
Rat FFAR2 FFAR2 292794 Q76EI6
FFAR2 233079 Q8VCK6
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Top FFAR2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

FFAR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Free Fatty Acid Receptor 2 (FFAR2) Interaction Partners

Human Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII (show TH Proteins) of FFA2, there are clear differences in how these interactions occur.

  2. FFAR2 signaling occurs by divergent G protein pathways.

  3. GPR3 agonism potentiates insulin secretion in isolated islets.

  4. GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1 (show XBP1 Proteins), while A549 cells overexpressing XBP1 (show XBP1 Proteins) displayed elevated GPR43 levels.

  5. FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis.

  6. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS Proteins) secretion by coupling to Gi-type G proteins.

  7. [review] In vivo and in vitro studies suggest that short-chain fatty acid receptors (SCFAs) stimulate gut (show GUSB Proteins) hormone secretion; therefore, the SCFA-FFA signal is likely to be important for gut (show GUSB Proteins) physiological functions.

  8. GPR43 modulates NF-kappaB (show NFKB1 Proteins) activity via beta-arrestin 2 (show ARRB2 Proteins).

  9. Propionate-stimulated GPR41 (show FFAR3 Proteins) strongly coupled to ERK1/2 activation, while the coupling of linoleic acid-activated GPR40 and acetate-activated GPR43 was weaker.

  10. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Mouse (Murine) Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. FFAR2 signaling occurs by divergent G protein pathways.

  2. Data (including data from studies in knockout mice) suggest Ffar2 expression in pancreatic beta-cells plays role in gestational glucose homeostasis; this mechanism involves gut microbiome (which contributes to plasma short-chain fatty acid levels).

  3. High fat diet fed GPR43 KO mice develop glucose intolerance due to a defect in insulin (show INS Proteins) secretion, reduced beta-cell mass and expression of differentiation genes. GPR3 (show GPR3 Proteins) agonism potentiates insulin (show INS Proteins) secretion.

  4. GPR-43-deficient mice show a greatly decreased inflammatory reaction to knee injection of monosodium urate crystals in a mouse model of gout.

  5. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS Proteins) secretion by coupling to Gi-type G proteins.

  6. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis.

  7. Data from transgenic mice suggest that Ffar2/Gpr43 and Ffar3/Gpr41 (show FFAR3 Proteins) both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar2/Gpr43 appears to play this role alone in enteric leukocytes and Ffar3/Gpr41 (show FFAR3 Proteins) alone in enteric neurons.

  8. Short-chain fatty acids activate GPR43 and on intestinal epithelial cells, leading to mitogen-activated protein kinase (show MAPK1 Proteins) signaling and rapid production of chemokines and cytokines. These pathways mediate protective immunity and tissue inflammation in mice.

  9. Data suggest that alpha-gustducin (show GNAT3 Proteins) in colonic mucosa is a key signaling molecule coupling free fatty acid receptors (Gpr43, Gpr119 (show GPR119 Proteins), Gpr120) and possibly bile acid receptor (show NR1H4 Proteins) (TGR5 (show GPBAR1 Proteins)) to secretion of GLP-1 (glucagon-like peptide 1 (show GCG Proteins)).

  10. Inulin-type fructans, paradoxically counteract GPR43 overexpression induced in the adipose tissue by an high fat diet.

FFAR2 Protein Profile

Protein Summary

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels.

Gene names and symbols associated with FFAR2

  • free fatty acid receptor 2 (FFAR2)
  • free fatty acid receptor 2 (Ffar2)
  • FFA2R protein
  • GPCR43 protein
  • Gpr43 protein

Protein level used designations for FFAR2

G protein-coupled receptor 43 , G-protein coupled receptor 43 , free fatty acid activated receptor 2 , leukocyte-specific STAT-induced GPCR

GENE ID SPECIES
2867 Homo sapiens
292794 Rattus norvegicus
233079 Mus musculus
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