anti-Free Fatty Acid Receptor 2 (FFAR2) Antibodies

FFAR2 encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. Additionally we are shipping FFAR2 Kits (5) and FFAR2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FFAR2 2867 O15552
FFAR2 292794 Q76EI6
FFAR2 233079 Q8VCK6
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Top anti-FFAR2 Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of COS7 cells, using FFAR2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse spleen labeled with Anti-GPR43 Polyclonal Antibody, Unconjugated (ABIN1713521) at 1:200 followed by conjugation to the secondary antibody and DAB staining Mouse splenocytes probed with Rabbit Anti-GPR43 Polyclonal Antibody, Unconjugated . 100 μL Log in to see 14 to 21 Days
$295.90
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB FFAR2 Antibody (C-term)  western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FFAR2 antibody detected the FFAR2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p) Immunofluorescence analysis of COS7 cells, using FFAR2 Antibody. The picture on the right is treated with the synthesized peptide. Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-GPR43 antibody  ABIN1048824 IHC staining of human spleen, neutorphils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-GPR43 antibody  ABIN1048823 IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GPR43 antibody  ABIN1048823 IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Gorilla Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
$515.63
Details

FFAR2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Rat (Rattus)


Mouse (Murine) , , ,


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Top referenced anti-FFAR2 Antibodies

  1. Human Polyclonal FFAR2 Primary Antibody for IF, ELISA - ABIN1535675 : Grimwood, Gordon, Olsen, Terry, Schmutz, Lamerdin, Hellsten, Goodstein, Couronne, Tran-Gyamfi, Aerts, Altherr, Ashworth, Bajorek, Black, Branscomb, Caenepeel, Carrano, Caoile, Chan, Christensen et al.: The DNA sequence and biology of human chromosome 19. ... in Nature 2004 (PubMed)

  2. Human Polyclonal FFAR2 Primary Antibody for FACS, IF (p) - ABIN1713521 : Kobayashi, Mikami, Kimura, Kamiyama, Morikawa, Yokoi, Kasuno, Takahashi, Taniguchi, Iwano: Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells. in Biochemical and biophysical research communications 2017 (PubMed)

More Antibodies against FFAR2 Interaction Partners

Human Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. Compared with the control group, the densitometric quantification and mean density of GPR43 and ChAT proteins, and expression of GPR43 and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.

  2. a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 and GPR41 (show FFAR3 Antibodies)

  3. Short-chain fatty acids lowered TNF-alpha (show TNF Antibodies)-induced MCP-1 (show CCL2 Antibodies) expression by reducing phosphorylation of p38 MAPK (show MAPK14 Antibodies) and JNK (show MAPK8 Antibodies) in a GPR41 (show FFAR3 Antibodies)/GRP43-dependent manner in renal cortical epithelial cells.

  4. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (show STK19 Antibodies) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (show GCG Antibodies) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (show STK19 Antibodies).

  5. the results of mutagenesis studies based on the crystal structure of hFFA1 bound to TAK (show CDK9 Antibodies)-875 at 2.3 A resolution to identify important residues for orthosteric agonist 6e inducing FFA2 activation.

  6. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII (show TH Antibodies) of FFA2, there are clear differences in how these interactions occur.

  7. FFAR2 signaling occurs by divergent G protein pathways.

  8. GPR3 agonism potentiates insulin secretion in isolated islets.

  9. GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1 (show XBP1 Antibodies), while A549 cells overexpressing XBP1 (show XBP1 Antibodies) displayed elevated GPR43 levels.

  10. FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis.

Mouse (Murine) Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. Gestational glucose tolerance in WT mice, but not Ffar2-/- mice improved while on antibiotics. Gestational glucose tolerance worsened in Ffar2-/- mice during a second pregnancy. Maternal Ffar2 expression had no effect on the growth rates and glucose and glucose tolerance in the offspring.

  2. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (show STK19 Antibodies) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (show GCG Antibodies) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (show STK19 Antibodies).

  3. A Western diet could aggravate the inflammatory colitis process; the activation of the GPR43 receptor pathway could be used as a new strategy to treat Crohn's Disease patients.

  4. FFAR2 signaling occurs by divergent G protein pathways.

  5. Data (including data from studies in knockout mice) suggest Ffar2 expression in pancreatic beta-cells plays role in gestational glucose homeostasis; this mechanism involves gut microbiome (which contributes to plasma short-chain fatty acid levels).

  6. High fat diet fed GPR43 KO mice develop glucose intolerance due to a defect in insulin (show INS Antibodies) secretion, reduced beta-cell mass and expression of differentiation genes. GPR3 (show GPR3 Antibodies) agonism potentiates insulin (show INS Antibodies) secretion.

  7. GPR-43-deficient mice show a greatly decreased inflammatory reaction to knee injection of monosodium urate crystals in a mouse model of gout.

  8. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS Antibodies) secretion by coupling to Gi-type G proteins.

  9. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis.

  10. Data from transgenic mice suggest that Ffar2/Gpr43 and Ffar3/Gpr41 (show FFAR3 Antibodies) both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar2/Gpr43 appears to play this role alone in enteric leukocytes and Ffar3/Gpr41 (show FFAR3 Antibodies) alone in enteric neurons.

FFAR2 Antigen Profile

Protein Summary

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels.

Gene names and symbols associated with FFAR2

  • free fatty acid receptor 2 (FFAR2) antibody
  • free fatty acid receptor 2 (Ffar2) antibody
  • FFA2R antibody
  • GPCR43 antibody
  • Gpr43 antibody

Protein level used designations for FFAR2

G protein-coupled receptor 43 , G-protein coupled receptor 43 , free fatty acid activated receptor 2 , leukocyte-specific STAT-induced GPCR

GENE ID SPECIES
2867 Homo sapiens
292794 Rattus norvegicus
233079 Mus musculus
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