Free Fatty Acid Receptor 2 Proteins (FFAR2)

FFAR2 encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. Additionally we are shipping FFAR2 Antibodies (83) and FFAR2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FFAR2 2867 O15552
Rat FFAR2 FFAR2 292794 Q76EI6
FFAR2 233079 Q8VCK6
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Top FFAR2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 11 to 12 Days
$491.43
Details

FFAR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Free Fatty Acid Receptor 2 (FFAR2) Interaction Partners

Human Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. Compared with the control group, the densitometric quantification and mean density of GPR43 and ChAT proteins, and expression of GPR43 and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.

  2. a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 and GPR41 (show FFAR3 Proteins)

  3. Short-chain fatty acids lowered TNF-alpha (show TNF Proteins)-induced MCP-1 (show CCL2 Proteins) expression by reducing phosphorylation of p38 MAPK (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) in a GPR41 (show FFAR3 Proteins)/GRP43-dependent manner in renal cortical epithelial cells.

  4. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (show STK19 Proteins) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (show GCG Proteins) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (show STK19 Proteins).

  5. the results of mutagenesis studies based on the crystal structure of hFFA1 bound to TAK (show CDK9 Proteins)-875 at 2.3 A resolution to identify important residues for orthosteric agonist 6e inducing FFA2 activation.

  6. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII (show TH Proteins) of FFA2, there are clear differences in how these interactions occur.

  7. FFAR2 signaling occurs by divergent G protein pathways.

  8. GPR3 agonism potentiates insulin secretion in isolated islets.

  9. GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1 (show XBP1 Proteins), while A549 cells overexpressing XBP1 (show XBP1 Proteins) displayed elevated GPR43 levels.

  10. FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis.

Mouse (Murine) Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. Gestational glucose tolerance in WT mice, but not Ffar2-/- mice improved while on antibiotics. Gestational glucose tolerance worsened in Ffar2-/- mice during a second pregnancy. Maternal Ffar2 expression had no effect on the growth rates and glucose and glucose tolerance in the offspring.

  2. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (show STK19 Proteins) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (show GCG Proteins) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (show STK19 Proteins).

  3. A Western diet could aggravate the inflammatory colitis process; the activation of the GPR43 receptor pathway could be used as a new strategy to treat Crohn's Disease patients.

  4. FFAR2 signaling occurs by divergent G protein pathways.

  5. Data (including data from studies in knockout mice) suggest Ffar2 expression in pancreatic beta-cells plays role in gestational glucose homeostasis; this mechanism involves gut microbiome (which contributes to plasma short-chain fatty acid levels).

  6. High fat diet fed GPR43 KO mice develop glucose intolerance due to a defect in insulin (show INS Proteins) secretion, reduced beta-cell mass and expression of differentiation genes. GPR3 (show GPR3 Proteins) agonism potentiates insulin (show INS Proteins) secretion.

  7. GPR-43-deficient mice show a greatly decreased inflammatory reaction to knee injection of monosodium urate crystals in a mouse model of gout.

  8. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS Proteins) secretion by coupling to Gi-type G proteins.

  9. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis.

  10. Data from transgenic mice suggest that Ffar2/Gpr43 and Ffar3/Gpr41 (show FFAR3 Proteins) both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar2/Gpr43 appears to play this role alone in enteric leukocytes and Ffar3/Gpr41 (show FFAR3 Proteins) alone in enteric neurons.

FFAR2 Protein Profile

Protein Summary

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels.

Gene names and symbols associated with FFAR2

  • free fatty acid receptor 2 (FFAR2)
  • free fatty acid receptor 2 (Ffar2)
  • FFA2R protein
  • GPCR43 protein
  • Gpr43 protein

Protein level used designations for FFAR2

G protein-coupled receptor 43 , G-protein coupled receptor 43 , free fatty acid activated receptor 2 , leukocyte-specific STAT-induced GPCR

GENE ID SPECIES
2867 Homo sapiens
292794 Rattus norvegicus
233079 Mus musculus
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