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Receptor for short chain fatty acids. Additionally we are shipping FFAR3 Antibodies (37) and FFAR3 Kits (5) and many more products for this protein.
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An inverse regulation of FFAR2 (show FFAR2 Proteins) and FFAR3 expression over time and both receptors also showed an inverse mRNA abundance as induced by different portions of concentrate. Thus, indicating divergent nutrient sensing of both receptors in adipose tissues (AT) during the transition period.
GPR41 gene contains 3 exons and its transcription is initiated at 2 leader exons, generating 2 GPR41 mRNA variants differing in the 5' untranslated region
Our data suggest that GPR42 be reclassified as a functioning gene and that recognition of sequence and copy number polymorphism of the FFAR3/GPR42 complex be considered during genetic and pharmacological investigation of these receptors.
FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin (show INS Proteins) secretion by coupling to Gi-type G proteins.
a significant correlation between a higher body mass index and lower methylation in the promoter region of FFAR3 in type 2 diabetes and obesity patients
Propionate-stimulated GPR41 strongly coupled to ERK1/2 activation, while the coupling of linoleic acid-activated GPR40 and acetate-activated GPR43 (show FFAR2 Proteins) was weaker.
GPR41 activation inhibits histone acetylation and cell growth.
GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins
Selective orthosteric free fatty acid receptor 2 (show FFAR2 Proteins) (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
characterization of GP41 in human tissue as a receptor for short chain fatty acids
C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor (show GPRC5D Proteins) GPR41, stimulate leptin (show LEP Proteins) expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture
GPR41 and 43 mediate SCFA signaling in mammary epithelial cells and thereby play an important role in their stress management.
Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gbetagamma-PLCbeta3-ERK1/2-synapsin 2 (show SYN2 Proteins)
mediates beta cell glucose stimulated insulin (show INS Proteins) secretion through Galphai/o sensitive pathway
Results indicate that FFAR3 is expressed on postganglionic sympathetic and sensory neurons in both the autonomic and somatic peripheral nervous system
Data from transgenic mice suggest that Ffar3/Gpr41 and Ffar2/Gpr43 (show FFAR2 Proteins) both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar3/Gpr41 appears to play this role alone in enteric neurons and Ffar2/Gpr43 (show FFAR2 Proteins) alone in enteric leukocytes.
Short-chain fatty acids activate GPR41 and on intestinal epithelial cells, leading to mitogen-activated protein kinase (show MAPK1 Proteins) signaling and rapid production of chemokines and cytokines. These pathways mediate protective immunity and tissue inflammation in mice.
Short chain fatty acids and ketone bodies directly regulate GPR41-mediated sympathetic nervous system activity and thereby control body energy expenditure in maintaining metabolic homeostasis.
Acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43 (show FFAR2 Proteins), but not through GPCR41 (show GPR172B Proteins).
Gpr41 is a regulator of host energy balance through effects that are dependent upon the gut (show GUSB Proteins) microbiota
Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate.
free fatty acid receptor 3
, G protein-coupled receptor 41
, G-protein coupled receptor 41
, putative G protein-coupled receptor GPR41