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anti-Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) Antibodies

The protein encoded by FRAT1 belongs to the GSK-3-binding protein family. Additionally we are shipping FRAT1 Proteins (4) and FRAT1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FRAT1 14296 P70339
FRAT1 10023 Q92837
FRAT1    
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Top anti-FRAT1 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of FRAT1 (arrow) using rabbit polyclonal FRAT1 Antibody (C-term) (ABIN388208). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the FRAT1 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FRAT1 antibody (C-term) (ABIN388208), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of FRAT1 (arrow) using rabbit polyclonal FRAT1 Antibody (Center) (ABIN388209).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the FRAT1 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FRAT1 antibody (Center) (ABIN388209), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged FRAT1 is 0.1 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

FRAT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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Top referenced anti-FRAT1 Antibodies

  1. Human Polyclonal FRAT1 Primary Antibody for IHC (p), WB - ABIN388208 : Hagen, Cross, Culbert, West, Frame, Morrice, Reith: FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. in The Journal of biological chemistry 2006 (PubMed)
    Show all 4 references for ABIN388208

  2. Human Polyclonal FRAT1 Primary Antibody for EIA, IHC (p) - ABIN356924 : Wang, Hewitt, Liu, Zhou, Zhu, Zhou, Zhang, Quan, Bai, Xu: Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. in British journal of cancer 2006 (PubMed)
    Show all 3 references for ABIN356924

  3. Human Polyclonal FRAT1 Primary Antibody for IHC (p), WB - ABIN388209 : Hino, Michiue, Asashima, Kikuchi: Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 references for ABIN388209

More Antibodies against FRAT1 Interaction Partners

Mouse (Murine) Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) interaction partners

  1. Gsk3b (show GSK3b Antibodies) is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt (show AKT1 Antibodies) activity results in dissociation of this complex and retention of Gsk3b (show GSK3b Antibodies) in the nucleus.

  2. Data show that that Frat synergizes with Diversin (show ANKRD6 Antibodies) in the activation of JNK (show MAPK8 Antibodies)/AP-1 (show JUN Antibodies) signaling.

  3. FRAT has a role in mediating GSK-3 (show GSK3b Antibodies) nuclear export in mouse cells

  4. Data suggest that recruitment of Axin (show AXIN1 Antibodies) and Frat1 to the membrane by LRP5 (show LRP5 Antibodies)-triggered Wnt3 (show WNT3 Antibodies) signaling leads to both Axin (show AXIN1 Antibodies) degradation and Frat1-mediated inhibition of glycogen synthase kinase-3 (show GSK3a Antibodies).

Human Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) interaction partners

  1. FRAT1 and ABCG2 (show ABCG2 Antibodies) overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with Pancreatic ductal adenocarcinoma.

  2. Positive ROR2 (show ROR2 Antibodies) and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma.

  3. FRAT1 overexpression correlates with pathologic grade, proliferation, invasion and angiogenesis in brain gliomas.

  4. The mechanism of inhibiting beta-catenin (show CTNNB1 Antibodies) phosphorylation involves the NDRG1 (show NDRG1 Antibodies)-mediated upregulation of the GSK3beta (show GSK3b Antibodies)-binding protein FRAT1.

  5. These results highlight the potential role of FRAT1 in tumorigenesis and progression of glioblastoma.

  6. The overexpression of Frat1 and beta-catenin (show CTNNB1 Antibodies) was correlated with tumor differentiation, TNM (show ODZ1 Antibodies) stage, lymph node metastasis, and poor prognosis of NSCLC.

  7. Down-regulation of Frat1 expression reduced invasive ability in A549 cell line, further supporting idea that Frat1 may play crucial role in carcinogenesis, tumor invasiveness and dissemination in human lung cancer.

  8. Elevated expression of FRAT1 was associated with astrocytomas.

  9. Our results suggest that FRAT1 may be an important factor in the tumorigenesis and progression of gliomas, and could be used as a potential molecular marker for pathological diagnosis and a target for biological therapy.

  10. CKI epsilon (show CSNK1E Antibodies)-dependent phosphorylation of Dvl (show DVL2 Antibodies) enhances the formation of a complex of Dvl-1 (show DVL1 Antibodies) with Frat-1 and this complex leads to the activation of Wnt-3a (show WNT3A Antibodies)-induced accumulation of beta-catenin (show CTNNB1 Antibodies)

FRAT1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.

Gene names and symbols associated with FRAT1

  • frequently rearranged in advanced T-cell lymphomas (FRAT1) antibody
  • GSK-3 binding protein FRAT1 (frat1) antibody
  • frequently rearranged in advanced T cell lymphomas (Frat1) antibody
  • frequently rearranged in advanced T-cell lymphomas (frat1) antibody
  • AW060382 antibody
  • frat1 antibody
  • gbp antibody

Protein level used designations for FRAT1

GSK-3 binding protein FRAT1 , frequently rearranged in advanced T-cell lymphomas , gsk3-binding protein , FRAT-1 , frequently rearranged in advanced T-cell lymphomas 1 , proto-oncogene FRAT1 , GSK-3 binding protein GBP , GSK-3-binding protein , gsk binding protein

GENE ID SPECIES
466169 Pan troglodytes
705609 Macaca mulatta
100303596 Saccoglossus kowalevskii
14296 Mus musculus
10023 Homo sapiens
486819 Canis lupus familiaris
398043 Xenopus laevis
505664 Bos taurus
Selected quality suppliers for anti-FRAT1 (FRAT1) Antibodies
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