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The protein encoded by FRAT1 belongs to the GSK-3-binding protein family. Additionally we are shipping FRAT1 Antibodies (29) and FRAT1 Proteins (4) and many more products for this protein.
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Gsk3b is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt activity results in dissociation of this complex and retention of Gsk3b in the nucleus.
Data show that that Frat synergizes with Diversin (show ANKRD6 ELISA Kits) in the activation of JNK (show MAPK8 ELISA Kits)/AP-1 (show JUN ELISA Kits) signaling.
FRAT has a role in mediating GSK-3 nuclear export in mouse cells
Data suggest that recruitment of Axin and Frat1 to the membrane by LRP5-triggered Wnt3 signaling leads to both Axin degradation and Frat1-mediated inhibition of glycogen synthase kinase-3.
FRAT1 and ABCG2 (show ABCG2 ELISA Kits) overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with Pancreatic ductal adenocarcinoma.
Positive ROR2 (show ROR2 ELISA Kits) and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma.
FRAT1 overexpression correlates with pathologic grade, proliferation, invasion and angiogenesis in brain gliomas.
The mechanism of inhibiting beta-catenin (show CTNNB1 ELISA Kits) phosphorylation involves the NDRG1 (show NDRG1 ELISA Kits)-mediated upregulation of the GSK3beta-binding protein FRAT1.
These results highlight the potential role of FRAT1 in tumorigenesis and progression of glioblastoma.
The overexpression of Frat1 and beta-catenin (show CTNNB1 ELISA Kits) was correlated with tumor differentiation, TNM (show ODZ1 ELISA Kits) stage, lymph node metastasis, and poor prognosis of NSCLC.
Down-regulation of Frat1 expression reduced invasive ability in A549 cell line, further supporting idea that Frat1 may play crucial role in carcinogenesis, tumor invasiveness and dissemination in human lung cancer.
Elevated expression of FRAT1 was associated with astrocytomas.
Our results suggest that FRAT1 may be an important factor in the tumorigenesis and progression of gliomas, and could be used as a potential molecular marker for pathological diagnosis and a target for biological therapy.
CKI epsilon (show CSNK1E ELISA Kits)-dependent phosphorylation of Dvl (show DVL2 ELISA Kits) enhances the formation of a complex of Dvl-1 (show DVL1 ELISA Kits) with Frat-1 and this complex leads to the activation of Wnt-3a (show WNT3A ELISA Kits)-induced accumulation of beta-catenin (show CTNNB1 ELISA Kits)
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.
GSK-3 binding protein FRAT1
, frequently rearranged in advanced T-cell lymphomas
, gsk3-binding protein
, frequently rearranged in advanced T-cell lymphomas 1
, proto-oncogene FRAT1
, GSK-3 binding protein GBP
, GSK-3-binding protein
, gsk binding protein