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Frequently Rearranged in Advanced T-Cell Lymphomas Proteins (FRAT1)

The protein encoded by FRAT1 belongs to the GSK-3-binding protein family. Additionally we are shipping FRAT1 Antibodies (29) and FRAT1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FRAT1 14296 P70339
FRAT1 10023 Q92837
FRAT1 398043 O93343
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Top FRAT1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,388.83
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details

FRAT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,
Xenopus laevis

More Proteins for Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) Interaction Partners

Mouse (Murine) Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) interaction partners

  1. Gsk3b is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt activity results in dissociation of this complex and retention of Gsk3b in the nucleus.

  2. Data show that that Frat synergizes with Diversin in the activation of JNK (show MAPK8 Proteins)/AP-1 (show JUN Proteins) signaling.

  3. FRAT has a role in mediating GSK-3 nuclear export in mouse cells

  4. Data suggest that recruitment of Axin and Frat1 to the membrane by LRP5-triggered Wnt3 signaling leads to both Axin degradation and Frat1-mediated inhibition of glycogen synthase kinase-3.

Human Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1) interaction partners

  1. FRAT1 and ABCG2 overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with Pancreatic ductal adenocarcinoma.

  2. Positive ROR2 (show ROR2 Proteins) and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma.

  3. FRAT1 overexpression correlates with pathologic grade, proliferation, invasion and angiogenesis in brain gliomas.

  4. The mechanism of inhibiting beta-catenin (show CTNNB1 Proteins) phosphorylation involves the NDRG1 (show NDRG1 Proteins)-mediated upregulation of the GSK3beta-binding protein FRAT1.

  5. These results highlight the potential role of FRAT1 in tumorigenesis and progression of glioblastoma.

  6. The overexpression of Frat1 and beta-catenin (show CTNNB1 Proteins) was correlated with tumor differentiation, TNM (show ODZ1 Proteins) stage, lymph node metastasis, and poor prognosis of NSCLC.

  7. Down-regulation of Frat1 expression reduced invasive ability in A549 cell line, further supporting idea that Frat1 may play crucial role in carcinogenesis, tumor invasiveness and dissemination in human lung cancer.

  8. Elevated expression of FRAT1 was associated with astrocytomas.

  9. Our results suggest that FRAT1 may be an important factor in the tumorigenesis and progression of gliomas, and could be used as a potential molecular marker for pathological diagnosis and a target for biological therapy.

  10. CKI epsilon (show CSNK1E Proteins)-dependent phosphorylation of Dvl (show DVL2 Proteins) enhances the formation of a complex of Dvl-1 (show DVL1 Proteins) with Frat-1 and this complex leads to the activation of Wnt-3a (show WNT3A Proteins)-induced accumulation of beta-catenin (show CTNNB1 Proteins)

FRAT1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.

Gene names and symbols associated with FRAT1

  • frequently rearranged in advanced T-cell lymphomas (FRAT1)
  • GSK-3 binding protein FRAT1 (frat1)
  • frequently rearranged in advanced T cell lymphomas (Frat1)
  • frequently rearranged in advanced T-cell lymphomas (frat1)
  • AW060382 protein
  • frat1 protein
  • gbp protein

Protein level used designations for FRAT1

GSK-3 binding protein FRAT1 , frequently rearranged in advanced T-cell lymphomas , gsk3-binding protein , FRAT-1 , frequently rearranged in advanced T-cell lymphomas 1 , proto-oncogene FRAT1 , GSK-3 binding protein GBP , GSK-3-binding protein , gsk binding protein

GENE ID SPECIES
466169 Pan troglodytes
705609 Macaca mulatta
100303596 Saccoglossus kowalevskii
14296 Mus musculus
10023 Homo sapiens
486819 Canis lupus familiaris
398043 Xenopus laevis
505664 Bos taurus
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