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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Additionally we are shipping Friend Leukemia Virus Integration 1 Kits (6) and Friend Leukemia Virus Integration 1 Proteins (6) and many more products for this protein.
Showing 10 out of 131 products:
Chicken Polyclonal FLI1 Primary Antibody for WB - ABIN2780392
van den Akker, van Dijk, Schmidt, Felida, Beug, Loewenberg, von Lindern: The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity. in Biological chemistry 2004
Show all 3 references for ABIN2780392
Human Polyclonal FLI1 Primary Antibody for IF, WB - ABIN390409
Embree, Azuma, Hickstein: Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines. in Cancer research 2009
Show all 2 references for ABIN390409
Human Polyclonal FLI1 Primary Antibody for IHC (p), WB - ABIN390410
Torlakovic, Slipicevic, Flørenes, Chibbar, DeCoteau, Bilalovic: Fli-1 expression in malignant melanoma. in Histology and histopathology 2008
Show all 2 references for ABIN390410
Human Polyclonal FLI1 Primary Antibody for WB - ABIN871657
Delattre, Zucman, Plougastel, Desmaze, Melot, Peter, Kovar, Joubert, de Jong, Rouleau: Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. in Nature 1992
Show all 2 references for ABIN871657
Human Monoclonal FLI1 Primary Antibody for IP, WB - ABIN967451
Bailly, Bosselut, Zucman, Cormier, Delattre, Roussel, Thomas, Ghysdael: DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. in Molecular and cellular biology 1994
Show all 2 references for ABIN967451
Chicken Polyclonal FLI1 Primary Antibody for WB - ABIN2774665
Miyagawa, Yamai, Sakaguchi, Kiyohara, Tsukamoto, Kimoto, Nakamura, Lee, Tsai, Chiang, Shimoda, Harada, Tahira, Hayashi, Horiuchi: Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. in Rheumatology (Oxford, England) 2008
FLI1 promoter hypermethylation is associated with Colorectal Cancer.
Concurrent exogenous expression of three transcription factors, GATA1 (show GATA1 Antibodies), FLI1 and TAL1 (show TAL1 Antibodies), enables large-scale production of megakaryocytes from human pluripotent stem cells.
Identify SP1 (show PSG1 Antibodies) and PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling as modulators of EWS (show EWSR1 Antibodies)/FLI1 gene expression in tumor cell lines.
This study for the first time identifies FLI1 as a clinically and functionally important target gene of metastasis, providing a rationale for developing FLI1 inhibitors in the treatment of breast cancer.
SLFN11 has a role as a transcriptional target of EWS (show EWSR1 Antibodies)-FLI1 and is a determinant of drug response in Ewing sarcoma
Overexpression of FLI1 and ERG (show ERG Antibodies) genes is sufficient to transdifferentiate erythroblasts to megakaryocytes that can produce functional platelets.
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
erythrocyte lineage enforces exclusivity through upregulation of EKLF (show KLF1 Antibodies) and its lineage-specific cytokine receptor (show EBI3 Antibodies) (EpoR (show EPOR Antibodies)) while inhibiting both FLI-1 and the receptor TpoR (show MPL Antibodies) (also known as MPL (show MPL Antibodies)) for the opposing megakaryocyte lineage
Case Report: SMARCB1 (show SMARCB1 Antibodies)-deficient vulvar sarcoma expressing ERG (show ERG Antibodies) and FLI1.
Mutation in FLI1 is associated with Paris-Trousseau thrombocytopenia.
These results provide the first evidences that Fli-1 positively regulates LPS (show TLR4 Antibodies)-induced IL-27 (show IL27 Antibodies) production in macrophages
protective against nephritis MRL/lpr (show FAS Antibodies) mice
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (show ETS1 Antibodies) and FLI1.
Simultaneous downregulation of KLF5 (show KLF5 Antibodies) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (show GATA2 Antibodies) are upstream regulators of SMAD1 (show SMAD1 Antibodies) and SMAD5 (show SMAD5 Antibodies) expression in endothelial cells.
These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine (show CCL1 Antibodies) MCP-1 (show CPT1B Antibodies).
Fli-1 directly increases the expression of IL-6 (show IL6 Antibodies) via promoter region binding. This represents one possible mechanism for the protective effect of decreased Fli-1 expression in lupus.
reducing FLI1 in lupus decreases the pathogenicity of T cells by decreasing TCR-specific activation and IL-4 (show IL4 Antibodies) production in part through the modulation of glycosphingolipid metabolism
Fli+ etsrp (show ETV2 Antibodies)+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (show GATA1 Antibodies) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp (show ETV2 Antibodies), demonstrated that erg (show KCNH2 Antibodies) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (show CDH5 Antibodies)
Interaction between EWSR1 (show EWSR1 Antibodies)/FLI1 and EWSR1 (show EWSR1 Antibodies) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Friend leukemia virus integration 1
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, proto-oncogene Fli-1
, transcription factor ERGB
, retroviral integration site protein Fli-1 homolog
, retroviral integration site protein Fli-1
, fli-1 proto-oncogene