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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Additionally we are shipping Friend Leukemia Virus Integration 1 Antibodies (127) and Friend Leukemia Virus Integration 1 Kits (6) and many more products for this protein.
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Concurrent exogenous expression of three transcription factors, GATA1 (show GATA1 Proteins), FLI1 and TAL1 (show TAL1 Proteins), enables large-scale production of megakaryocytes from human pluripotent stem cells.
Identify SP1 (show PSG1 Proteins) and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling as modulators of EWS (show EWSR1 Proteins)/FLI1 gene expression in tumor cell lines.
This study for the first time identifies FLI1 as a clinically and functionally important target gene of metastasis, providing a rationale for developing FLI1 inhibitors in the treatment of breast cancer.
SLFN11 has a role as a transcriptional target of EWS (show EWSR1 Proteins)-FLI1 and is a determinant of drug response in Ewing sarcoma
Overexpression of FLI1 and ERG (show ERG Proteins) genes is sufficient to transdifferentiate erythroblasts to megakaryocytes that can produce functional platelets.
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
erythrocyte lineage enforces exclusivity through upregulation of EKLF (show KLF1 Proteins) and its lineage-specific cytokine receptor (show EBI3 Proteins) (EpoR (show EPOR Proteins)) while inhibiting both FLI-1 and the receptor TpoR (show MPL Proteins) (also known as MPL (show MPL Proteins)) for the opposing megakaryocyte lineage
Case Report: SMARCB1 (show SMARCB1 Proteins)-deficient vulvar sarcoma expressing ERG (show ERG Proteins) and FLI1.
Mutation in FLI1 is associated with Paris-Trousseau thrombocytopenia.
Fli-1 expression gradually increases in parallel with disease progression.
These results provide the first evidences that Fli-1 positively regulates LPS (show TLR4 Proteins)-induced IL-27 (show IL27 Proteins) production in macrophages
protective against nephritis MRL/lpr (show FAS Proteins) mice
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (show ETS1 Proteins) and FLI1.
Simultaneous downregulation of KLF5 (show KLF5 Proteins) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (show GATA2 Proteins) are upstream regulators of SMAD1 (show SMAD1 Proteins) and SMAD5 (show SMAD5 Proteins) expression in endothelial cells.
These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine (show CCL1 Proteins) MCP-1 (show CPT1B Proteins).
Fli-1 directly increases the expression of IL-6 (show IL6 Proteins) via promoter region binding. This represents one possible mechanism for the protective effect of decreased Fli-1 expression in lupus.
reducing FLI1 in lupus decreases the pathogenicity of T cells by decreasing TCR-specific activation and IL-4 (show IL4 Proteins) production in part through the modulation of glycosphingolipid metabolism
Fli+ etsrp (show ETV2 Proteins)+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (show GATA1 Proteins) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp (show ETV2 Proteins), demonstrated that erg (show KCNH2 Proteins) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (show CDH5 Proteins)
Interaction between EWSR1 (show EWSR1 Proteins)/FLI1 and EWSR1 (show EWSR1 Proteins) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Friend leukemia virus integration 1
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, proto-oncogene Fli-1
, transcription factor ERGB
, retroviral integration site protein Fli-1 homolog
, retroviral integration site protein Fli-1
, fli-1 proto-oncogene