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FUT8 encodes an enzyme belonging to the family of fucosyltransferases. Additionally we are shipping FUT8 Kits (17) and FUT8 Proteins (11) and many more products for this protein.
Showing 10 out of 58 products:
our study provides the first direct evidence for the involvement of Fut8 in liver regeneration.
Loss of core fucosylation on AMPARs enhanced their heteromerization, which increase sensitivity for postsynaptic depolarization and persistently activate N-methyl-d-aspartate receptors as well as Ca(2 (show CA2 Antibodies)+) influx and CaMKII (show CAMK2G Antibodies) and then impair LTP (show SCP2 Antibodies).
findings define FUT8 as a novel factor for hemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation
FUT8 is up-regulated during epithelial-mesenchymal transition (EMT (show ITK Antibodies)), a critical process for malignant transformation of tumor, via the transactivation of beta-catenin (show CTNNB1 Antibodies)/lymphoid enhancer-binding factor-1 (LEF-1 (show LEF1 Antibodies)).
These data suggest that reduced Fut8 activity is associated with the progression of COPD (show ARCN1 Antibodies) and serum Fut8 activity is a non-invasive predictive biomarker candidate for progression and exacerbation of COPD (show ARCN1 Antibodies).
Increased expression and activity of alpha-1,6-fucosyltransferase (FUT8) in the liver are strongly linked to the age-related changes in protein glycosylation.
epidermal growth factor (show EGF Antibodies) induced phosphorylation levels of the EGF receptor (EGFR (show EGFR Antibodies)) were substantially blocked in Fut8-/- cells. Consistent with this, EGFR (show EGFR Antibodies)-mediated JNK (show MAPK8 Antibodies) or ERK (show EPHB2 Antibodies) activation was significantly suppressed in Fut8-/- cells.
EGFR (show EGFR Antibodies)-trypsin-PAR-2 (show F2RL1 Antibodies) pathway is suppressed in Fut8-/- mice.
Reduced alpha4 1 integrin/vascular cell adhesion molecule 1 (show VCAM1 Antibodies) interactions lead to impaired pre-B cell repopulation in alpha 1,6-fucosyltransferase deficient mice
Vascular endothelial growth factor receptor-2 (VEGFR-2 (show KDR Antibodies)) expression was significantly suppressed in Fut8(-/-) mice, suggesting that Fut8 was required for VEGFR-2 (show KDR Antibodies) expression.
FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination.
The production of the homogeneous core-fucosylated Man5GlcNAc2 glycoform of EPO (show EPO Antibodies) in the FUT8-overexpressed HEK293S GnT I (show MGAT1 Antibodies)(-/-) cell line represents the first example of production of fully core-fucosylated high-mannose glycoforms.
Expression of FUT8 can stratify breast cancer tissue and may be considered a prognostic marker for breast cancer patients
MiR (show MLXIP Antibodies)-198 was shown to target the 3'UTR (show UTS2R Antibodies) of FUT8 directly to downregulate FUT8 expression.
High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor.
Our results suggest that FUT8 may be associated with aggressive PCa (show FLVCR1 Antibodies) and thus is potentially useful for its prognosis.
miR (show MLXIP Antibodies)-122 and miR (show MLXIP Antibodies)-34a are able to target FUT8 3'UTR (show UTS2R Antibodies)
Results suggest that FUT4 (show FUT4 Antibodies)-, FUT6 (show FUT6 Antibodies)- or FUT8-mediated MDR in human HCC (show FAM126A Antibodies) is associated with the activation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway and the expression of MRP1 (show MDM4 Antibodies).
alpha 1,6-fucosyltransferase 8 expression might be a good indicator of poor prognosis in hepatocellular carcinoma. High alpha 1,6-fucosyltransferase 8 expression may play an important role in hepatitis B virus-related hepatocellular carcinoma progression
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.
, GDP-fucose--glycoprotein fucosyltransferase
, alpha (1,6) fucosyltransferase
, glycoprotein 6-alpha-L-fucosyltransferase
, Glycoprotein 6-alpha-L-fucosyltransferase
, alpha 1,6 fucosyltransferase