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Fumarate Hydratase Proteins (FH)

The protein encoded by FH is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. Additionally we are shipping FH Antibodies (134) and FH Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FH 2271 P07954
FH 24368  
FH 14194 P97807
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Top FH Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$309.75
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,312.83
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,312.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,312.83
Details
HOST_Escherichia coli (E. coli) Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details

FH Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced FH Proteins

  1. Human FH Protein expressed in Escherichia coli (E. coli) - ABIN2181102 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 3 references for ABIN2181102

  2. Human FH Protein expressed in Escherichia coli (E. coli) - ABIN666730 : Lehtonen, Kiuru, Rökman, Ikonen, Cunningham, Schaid, Matikainen, Nupponen, Karhu, Kallioniemi, Thibodeau, Schleutker, Aaltonen: No fumarate hydratase (FH) mutations in hereditary prostate cancer. in Journal of medical genetics 2003 (PubMed)
    Show all 2 references for ABIN666730

More Proteins for Fumarate Hydratase (FH) Interaction Partners

Human Fumarate Hydratase (FH) interaction partners

  1. A novel deletion of the Fumarate Hydratase (FH) gene was identified in a 22 year old male and his father, which predisposes to an aggressive form of renal cell cancer.

  2. While the great majority of patients with hereditary leiomyomatosis and renal cell carcinoma (show MOK Proteins) will have FH-deficient leiomyomas, 1% of all uterine leiomyomas are FH deficient usually due to somatic inactivation.

  3. significant association with overall survival were confirmed for SDHC (show SDHC Proteins) gene, SDHD (show SDHD Proteins) gene and FH gene ... SDHC (show SDHC Proteins) gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma

  4. Describe a novel mutation in the fumarate hydratase gene in a family with atypical uterine leiomyomas and hereditary leiomyomatosis and renal cell cancer.

  5. Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval

  6. Morphology and immunohistochemistry for fumarate hydratase aid in detection of fumarate hydratase mutations in uterine leiomyomas from young patients.

  7. Case report of a family with a fumarate hydratase mutation causing uterine leiomyomas and renal cell cancer.

  8. A multiplex snapback primer system was developed for the simultaneous detection of JAK2 (show JAK2 Proteins) V617F and MPL (show MPL Proteins) W515L/K mutations in Philadelphia chromosome- (Ph-) negative myeloproliferative neoplasms (MPNs).

  9. Novel missense mutation has been found in the fumarate hydratase gene in familial renal cell cancer patients lacking cutaneous leiomyomas.

  10. These results extend the range of clinical and biochemical variation associated with fumarase deficiency.

Mouse (Murine) Fumarate Hydratase (FH) interaction partners

  1. Reexpression of cytosolic FH in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway.

  2. Tumor-derived FH and SDH (show SDS Proteins) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Proteins).

  3. identification of a metabolic pathway that is induced in Fh1-deficient cells to demonstrate that inhibition of haem oxygenation is synthetically lethal when combined with Fh1 deficiency, providing a new potential target for treating HLRCC patients

  4. These experiments demonstrated that upregulation of HIF-1alpha (show HIF1A Proteins) occurs as a direct consequence of FH inactivation.

  5. progression of tumors where FH is lost might be boosted by activation of the MET oncogene (show RAB1A Proteins), which is able to drive cell-autonomous tumor progression

FH Protein Profile

Protein Summary

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Gene names and symbols associated with Fumarate Hydratase Proteins (FH)

  • fumarate hydratase (FH)
  • fumarate hydratase (fumH)
  • fumarate hydratase (Fh)
  • fumarate hydratase (fh)
  • fumarate hydratase 1 (Fh1)
  • DDBDRAFT_0205237 protein
  • DDBDRAFT_0231397 protein
  • DDBDRAFT_0231400 protein
  • DDB_0205237 protein
  • DDB_0231397 protein
  • DDB_0231400 protein
  • Fh protein
  • Fh-1 protein
  • Fh1 protein
  • HLRCC protein
  • im:7152785 protein
  • LRCC protein
  • MCL protein
  • MCUL1 protein
  • ns:zf-e152 protein
  • zf-e152 protein
  • zgc:66253 protein
  • zgc:77498 protein

Protein level used designations for Fumarate Hydratase Proteins (FH)

fumarate hydratase, mitochondrial , fumarate hydratase , fumarase , fumarate hydratase 1 , EF-3

GENE ID SPECIES
100302102 Ovis aries
100060381 Equus caballus
707542 Macaca mulatta
420969 Gallus gallus
457851 Pan troglodytes
100172452 Pongo abelii
8622588 Dictyostelium discoideum AX4
2271 Homo sapiens
24368 Rattus norvegicus
480092 Canis lupus familiaris
100627128 Sus scrofa
520260 Bos taurus
393938 Danio rerio
14194 Mus musculus
Selected quality suppliers for FH Proteins (FH)
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