anti-Fumarate Hydratase (FH) Antibodies

The protein encoded by FH is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. Additionally we are shipping FH Kits (22) and FH Proteins (22) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FH 2271 P07954
FH 24368  
FH 14194 P97807
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Top anti-FH Antibodies at antibodies-online.com

Showing 10 out of 190 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB FH monoclonal antibody (M09), clone 3E7 Western Blot analysis of FH expression in HeLa on formalin-fixed paraffin-embedded human seminoma (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated ELISA, WB ABIN190758 (0.01µg/ml) staining of Human Kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to FH on HeLa cell (antibody concentration 10 µg/mL). FH monoclonal antibody (M07), clone 5C12 Western Blot analysis of FH expression in HeLa. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Western Blot: Fumarase Antibody [NBP1-31336] - A: HeLa B: Hep G2. Western Blot: Fumarase Antibody [NBP1-31336] - Rat liver. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Mouse Un-conjugated IP, ELISA, WB 100 μg Log in to see 20 to 21 Days
$218.90
Details
Chicken Goat Un-conjugated IHC (p), ELISA, WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated WB FH Antibody (N-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the FH  Antibody detected the FH  protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB FH monoclonal antibody (M01), clone 2E10. Western Blot analysis of FH expression in HeLa . Detection limit for recombinant GST tagged FH is approximately 3ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 20 to 21 Days
$218.90
Details

FH Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-FH Antibodies

  1. Human Monoclonal FH Primary Antibody for ELISA, WB - ABIN515646 : Kov?ová, Mrá?ek, N?sková, Holzerová, Vrbacký, Pecina, Hejzlarová, K?u?ková, Rohlena, Neuzil, Houšt?k: High molecular weight forms of mammalian respiratory chain complex II. in PLoS ONE 2013 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal FH Primary Antibody for ELISA, WB - ABIN253302 : Pollard, Spencer-Dene, Shukla, Howarth, Nye, El-Bahrawy, Deheragoda, Joannou, McDonald, Martin, Igarashi, Varsani-Brown, Rosewell, Poulsom, Maxwell, Stamp, Tomlinson: Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. in Cancer cell 2007 (PubMed)

  3. Human Polyclonal FH Primary Antibody for ICC, IF - ABIN441343 : Burkart, Tan, Warren, Iovino, Hughes, Kahn, Patti: Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function. in Scientific reports 2016 (PubMed)

More Antibodies against FH Interaction Partners

Human Fumarate Hydratase (FH) interaction partners

  1. We show that the mechanism of fumarate hydratase distribution is alternative transcription initiation from a broad promoter.

  2. fumarate increases ferritin (show FTL Antibodies) gene transcription by activating the NRF2 (show GABPA Antibodies) (nuclear factor [erythroid-derived 2]-like 2) transcription factor.

  3. FH-Ser75 phosphorylation level inversely correlates with the OGT (show OGT Antibodies) level and poor prognosis in pancreatic cancer patients. Report mechanism underlying transcription regulation by FH and the linkage between dysregulated OGT (show OGT Antibodies) activity and growth advantage of cancer cells under glucose deficiency.

  4. Loss of FH immunohistochemical (IHC) expression in cutaneous leiomyomas is a sensitive and specific marker for detection of hereditary leiomyomatosis and renal cell carcinoma (show MOK Antibodies) (HLRCC). FH expression by IHC was absent in 9 specimens and retained in 85 specimens and 2 cases were equivocal with minimal FH expression while succinate dehydrogenase B (show SDHB Antibodies) expression was retained in 95 specimens and equivocal in 1 specimen.

  5. LSH (show HELLS Antibodies) promoted cancer progression in part by regulating expression of fumarate hydratase (FH).

  6. Cascade FH mutation screening enabled the early diagnosis of a renal tumour in an asymptomatic parent of a child with fumarate hydratase deficiency, resulting in timely and possibly life-saving treatment.

  7. Mutations in some enzymes of the TCA cycle: Isocitrate dehydrogenase (IDH (show IDH1 Antibodies)), succinate dehydrogenase (SDH (show SDHA Antibodies)) and fumarate hydratase (FH) are associated with the accumulation of metabolites that are able to influence many aspects of cancer development and progression and for this reason are termed onco-metabolites.

  8. After indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase (show SDHA Antibodies), FH and MCT (show MCAT Antibodies) expression were increased. After the MCT1 (show CMA1 Antibodies)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.

  9. A novel deletion of the Fumarate Hydratase (FH) gene was identified in a 22 year old male and his father, which predisposes to an aggressive form of renal cell cancer.

  10. While the great majority of patients with hereditary leiomyomatosis and renal cell carcinoma (show MOK Antibodies) will have FH-deficient leiomyomas, 1% of all uterine leiomyomas are FH deficient usually due to somatic inactivation.

Mouse (Murine) Fumarate Hydratase (FH) interaction partners

  1. roles for fumarate metabolism in hematopoietic stem cell (HSC) maintenance and hematopoietic differentiation and reveal a differential requirement for mitochondrial Fh1 in normal hematopoiesis and leukemia propagation.

  2. Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin (show INS Antibodies) Resistance.

  3. Reexpression of cytosolic FH in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway.

  4. Tumor-derived FH and SDH (show SDS Antibodies) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Antibodies).

  5. identification of a metabolic pathway that is induced in Fh1-deficient cells to demonstrate that inhibition of haem oxygenation is synthetically lethal when combined with Fh1 deficiency, providing a new potential target for treating HLRCC patients

  6. These experiments demonstrated that upregulation of HIF-1alpha (show HIF1A Antibodies) occurs as a direct consequence of FH inactivation.

  7. progression of tumors where FH is lost might be boosted by activation of the MET oncogene (show RAB1A Antibodies), which is able to drive cell-autonomous tumor progression

FH Antigen Profile

Protein Summary

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Gene names and symbols associated with anti-Fumarate Hydratase (FH) Antibodies

  • fumarate hydratase (FH) antibody
  • fumarate hydratase (fumH) antibody
  • fumarate hydratase (Fh) antibody
  • fumarate hydratase (fh) antibody
  • fumarate hydratase 1 (Fh1) antibody
  • DDBDRAFT_0205237 antibody
  • DDBDRAFT_0231397 antibody
  • DDBDRAFT_0231400 antibody
  • DDB_0205237 antibody
  • DDB_0231397 antibody
  • DDB_0231400 antibody
  • Fh antibody
  • Fh-1 antibody
  • Fh1 antibody
  • HLRCC antibody
  • im:7152785 antibody
  • LRCC antibody
  • MCL antibody
  • MCUL1 antibody
  • ns:zf-e152 antibody
  • zf-e152 antibody
  • zgc:66253 antibody
  • zgc:77498 antibody

Protein level used designations for anti-Fumarate Hydratase (FH) Antibodies

fumarate hydratase, mitochondrial , fumarate hydratase , fumarase , fumarate hydratase 1 , EF-3

GENE ID SPECIES
100302102 Ovis aries
100060381 Equus caballus
707542 Macaca mulatta
420969 Gallus gallus
457851 Pan troglodytes
100172452 Pongo abelii
8622588 Dictyostelium discoideum AX4
2271 Homo sapiens
24368 Rattus norvegicus
480092 Canis lupus familiaris
100627128 Sus scrofa
520260 Bos taurus
393938 Danio rerio
14194 Mus musculus
Selected quality suppliers for anti-FH (FH) Antibodies
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