Fumarate Hydratase Proteins (FH)

The protein encoded by FH is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. Additionally we are shipping FH Antibodies (160) and FH Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FH 2271 P07954
FH 24368  
FH 14194 P97807
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Top FH Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$270.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 15 to 19 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 20 to 21 Days
$327.80
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$460.85
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 4 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 15 to 16 Days
$300.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

FH Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Rat (Rattus)

Mouse (Murine)
,

Top referenced FH Proteins

  1. Human FH Protein expressed in Escherichia coli (E. coli) - ABIN2181102 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 3 references for 2181102

  2. Human FH Protein expressed in Escherichia coli (E. coli) - ABIN666730 : Lehtonen, Kiuru, Rökman, Ikonen, Cunningham, Schaid, Matikainen, Nupponen, Karhu, Kallioniemi, Thibodeau, Schleutker, Aaltonen: No fumarate hydratase (FH) mutations in hereditary prostate cancer. in Journal of medical genetics 2003 (PubMed)
    Show all 2 references for 666730

More Proteins for Fumarate Hydratase (FH) Interaction Partners

Human Fumarate Hydratase (FH) interaction partners

  1. fumarate increases ferritin (show FTL Proteins) gene transcription by activating the NRF2 (show GABPA Proteins) (nuclear factor [erythroid-derived 2]-like 2) transcription factor.

  2. FH-Ser75 phosphorylation level inversely correlates with the OGT (show OGT Proteins) level and poor prognosis in pancreatic cancer patients. Report mechanism underlying transcription regulation by FH and the linkage between dysregulated OGT (show OGT Proteins) activity and growth advantage of cancer cells under glucose deficiency.

  3. Loss of FH immunohistochemical (IHC) expression in cutaneous leiomyomas is a sensitive and specific marker for detection of hereditary leiomyomatosis and renal cell carcinoma (show MOK Proteins) (HLRCC). FH expression by IHC was absent in 9 specimens and retained in 85 specimens and 2 cases were equivocal with minimal FH expression while succinate dehydrogenase B (show SDHB Proteins) expression was retained in 95 specimens and equivocal in 1 specimen.

  4. LSH (show HELLS Proteins) promoted cancer progression in part by regulating expression of fumarate hydratase (FH).

  5. Cascade FH mutation screening enabled the early diagnosis of a renal tumour in an asymptomatic parent of a child with fumarate hydratase deficiency, resulting in timely and possibly life-saving treatment.

  6. Mutations in some enzymes of the TCA cycle: Isocitrate dehydrogenase (IDH (show IDH1 Proteins)), succinate dehydrogenase (SDH (show SDHA Proteins)) and fumarate hydratase (FH) are associated with the accumulation of metabolites that are able to influence many aspects of cancer development and progression and for this reason are termed onco-metabolites.

  7. After indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase (show SDHA Proteins), FH and MCT (show MCAT Proteins) expression were increased. After the MCT1 (show CMA1 Proteins)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.

  8. A novel deletion of the Fumarate Hydratase (FH) gene was identified in a 22 year old male and his father, which predisposes to an aggressive form of renal cell cancer.

  9. While the great majority of patients with hereditary leiomyomatosis and renal cell carcinoma (show MOK Proteins) will have FH-deficient leiomyomas, 1% of all uterine leiomyomas are FH deficient usually due to somatic inactivation.

  10. significant association with overall survival were confirmed for SDHC (show SDHC Proteins) gene, SDHD (show SDHD Proteins) gene and FH gene ... SDHC (show SDHC Proteins) gene and FH gene were the primary factors contributing to the different overall survival time of colorectal carcinoma

Mouse (Murine) Fumarate Hydratase (FH) interaction partners

  1. roles for fumarate metabolism in hematopoietic stem cell (HSC) maintenance and hematopoietic differentiation and reveal a differential requirement for mitochondrial Fh1 in normal hematopoiesis and leukemia propagation.

  2. Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin (show INS Proteins) Resistance.

  3. Reexpression of cytosolic FH in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway.

  4. Tumor-derived FH and SDH (show SDS Proteins) mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation (show HELLS Proteins).

  5. identification of a metabolic pathway that is induced in Fh1-deficient cells to demonstrate that inhibition of haem oxygenation is synthetically lethal when combined with Fh1 deficiency, providing a new potential target for treating HLRCC patients

  6. These experiments demonstrated that upregulation of HIF-1alpha (show HIF1A Proteins) occurs as a direct consequence of FH inactivation.

  7. progression of tumors where FH is lost might be boosted by activation of the MET oncogene (show RAB1A Proteins), which is able to drive cell-autonomous tumor progression

FH Protein Profile

Protein Summary

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Gene names and symbols associated with Fumarate Hydratase Proteins (FH)

  • fumarate hydratase (FH)
  • fumarate hydratase (fumH)
  • fumarate hydratase (Fh)
  • fumarate hydratase (fh)
  • fumarate hydratase 1 (Fh1)
  • DDBDRAFT_0205237 protein
  • DDBDRAFT_0231397 protein
  • DDBDRAFT_0231400 protein
  • DDB_0205237 protein
  • DDB_0231397 protein
  • DDB_0231400 protein
  • Fh protein
  • Fh-1 protein
  • Fh1 protein
  • HLRCC protein
  • im:7152785 protein
  • LRCC protein
  • MCL protein
  • MCUL1 protein
  • ns:zf-e152 protein
  • zf-e152 protein
  • zgc:66253 protein
  • zgc:77498 protein

Protein level used designations for Fumarate Hydratase Proteins (FH)

fumarate hydratase, mitochondrial , fumarate hydratase , fumarase , fumarate hydratase 1 , EF-3

GENE ID SPECIES
100302102 Ovis aries
100060381 Equus caballus
707542 Macaca mulatta
420969 Gallus gallus
457851 Pan troglodytes
100172452 Pongo abelii
8622588 Dictyostelium discoideum AX4
2271 Homo sapiens
24368 Rattus norvegicus
480092 Canis lupus familiaris
100627128 Sus scrofa
520260 Bos taurus
393938 Danio rerio
14194 Mus musculus
Selected quality suppliers for FH Proteins (FH)
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