anti-Fused in Sarcoma (FUS) Antibodies

FUS encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. Additionally we are shipping FUS Kits (3) and FUS Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FUS 2521 P35637
FUS 233908 P56959
FUS 317385  
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Top anti-FUS Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB Flow cytometric analysis of Hela cells using FUS Antibody (C-term) Cat.-No AP51735PU-N (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Confocal immunofluorescent analysis of FUS Antibody (C-term) Cat.-No AP51735PU-N with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of TLS on a Jurkat cell lysate. Lane 1: 1:250, Lane 2: 1:500, Lane 3: 1:1000 dilution of the anti- TLS antibody. 50 μg Log in to see 6 to 8 Days
$154.07
Details
Human Rabbit Un-conjugated IHC (p), IP, WB 50 μL Log in to see 7 to 9 Days
$595.83
Details
Human Rabbit Un-conjugated IHC (p), WB Human Breast (formalin-fixed, paraffin-embedded) stained with FUS antibody ABIN462224 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Small Intestine (formalin-fixed, paraffin-embedded) stained with FUS antibody ABIN462224 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL Log in to see 7 to 9 Days
$390.50
Details
Mouse Rabbit Biotin ELISA, WB   100 μg Log in to see 7 to 9 Days
$566.50
Details
Human Rabbit HRP IHC, ELISA, WB   100 μg Log in to see 7 to 9 Days
$581.17
Details
Human Rabbit Biotin IHC, ELISA, WB   100 μg Log in to see 7 to 9 Days
$581.17
Details
Human Rabbit FITC IHC, ELISA, WB   100 μg Log in to see 7 to 9 Days
$581.17
Details
Mouse Rabbit FITC ELISA, WB   100 μg Log in to see 7 to 9 Days
$595.83
Details

FUS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FUS Antibodies

  1. Human Monoclonal FUS Primary Antibody for IF, WB - ABIN968508 : Hallier, Lerga, Barnache, Tavitian, Moreau-Gachelin: The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. in The Journal of biological chemistry 1998 (PubMed)
    Show all 5 references for 968508

  2. Human Polyclonal FUS Primary Antibody for EIA, FACS - ABIN952406 : Kim, Shanware, Bowler, Tibbetts: Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for 952406

More Antibodies against FUS Interaction Partners

Human Fused in Sarcoma (FUS) interaction partners

  1. Results expand the spectrum of tumor types harboring EWSR1 (show EWSR1 Antibodies)/FUS-ATF1 (show AFT1 Antibodies) gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.

  2. Aggregation of FET proteins FUS, EWSR1 (show EWSR1 Antibodies), and TAF15 (show TAF15 Antibodies) mediate a pathological change in amyotrophic lateral sclerosis. (Review)

  3. Focus on the recent advances on approaches to uncover the mechanisms of wild type and mutant FUS proteins during development and in neurodegeneration (review).

  4. FUS-induced reductions to ER-mitochondria associations and are linked to activation of glycogen synthase kinase-3beta (GSK-3beta (show GSK3b Antibodies)), a kinase already strongly associated with ALS (show IGFALS Antibodies)/FTD (show FTL Antibodies).

  5. Motor-neuron disease (MND (show CLN8 Antibodies))-linked RNA-binding proteins (RBPs), TDP-43 (show TARDBP Antibodies), FUS, and hnRNPA2B1 (show HNRNPA2B1 Antibodies), bind to and induce structural alteration of UGGAAexp. These RBPs suppress UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp folding and regulation of pentapeptide repeat translation.

  6. we analyzed fast axonal transport in larval motor neurons of Drosophila models of TARDBP (TDP-43 (show TARDBP Antibodies)), FUS and C9orf72 (show C9ORF72 Antibodies). We also analyzed the effect of loss-of-function mutants of the Drosophila orthologs of TDP-43 (show TARDBP Antibodies) and FUS, TBPH and caz, respectively. The motor activities of larvae and adults in these models were assessed to correlate potential defects in axonal transport with locomotor deficits

  7. These findings suggest a possible pathomechanism for amyotrophic lateral sclerosis in which mutated FUS inhibits correct splicing of minor introns in mRNAs encoding proteins required for motor neuron survival.

  8. This study revealed a characteristic phenotype in FUS/TLS-linked FALS patients in Japan.

  9. The aim of this review will be to provide a general overview of TDP-43 (show TARDBP Antibodies) and FUS/TLS proteins and to highlight their physiological functions--{REVIEW}

  10. Mouse model that overexpresses FUS without a nuclear localization signal (DeltaNLS-FUS) shows progressive motor deficits/ALS phenotype

Mouse (Murine) Fused in Sarcoma (FUS) interaction partners

  1. FUS-induced reductions to ER-mitochondria associations and are linked to activation of glycogen synthase kinase-3beta (GSK-3beta (show GSK3b Antibodies)), a kinase already strongly associated with ALS/FTD (show FTL Antibodies).

  2. our findings indicate that cytoplasmic FUS mislocalization not only leads to nuclear loss of function, but also triggers motor neuron death through a toxic gain of function within motor neurons.

  3. The data of this study support the notion that expression of cytoplasmically mislocalized FUS with compromised RNA-binding capacity causes particularly prominent and harmful FUS pathology in the mouse nervous system.

  4. These results highlight the pivotal role of FUS in regulating GluA1 (show GRIA1 Antibodies) mRNA stability, post-synaptic function and fronto-temporal lobar degeneration-like animal behaviors.

  5. these studies establish potentially converging disease mechanisms in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy, with ALS-causative mutants acquiring properties representing both gain and loss of function.

  6. FUS/TLS depletion causes phenotypes possibly related to neuropsychiatric and neurodegenerative conditions, but distinct from ALS and ET, together with specific alterations in RNA metabolisms.

  7. It is associated with amyotrophic lateral sclerosis and its mutation causes accumulation of fus positive stress granules in neurons.

  8. Study provides evidence for loss of PRMT1 (show PRMT1 Antibodies) function as a consequence of cytoplasmic accumulation of FUS in the pathogenesis of amyotrophic lateral sclerosis, including changes in the histone code regulating gene transcription.

  9. our study provided evidence that a multistep process of FUS aggregation in the cell cytoplasm includes RNA-dependent and RNA-independent mechanisms.

  10. Activation of metabotropic glutamate (show GRIN1 Antibodies) receptors 1/5 in neocortical slices and isolated synaptoneurosomes increases endogenous mouse FUS and FUS(WT) protein levels but decreases the FUS(R521G) protein

FUS Antigen Profile

Protein Summary

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.

Gene names and symbols associated with anti-Fused in Sarcoma (FUS) Antibodies

  • fused in sarcoma (FUS) antibody
  • fused in sarcoma (Fus) antibody
  • ALS6 antibody
  • D430004D17Rik antibody
  • D930039C12Rik antibody
  • ETM4 antibody
  • FUS/TLS antibody
  • Fus1 antibody
  • HNRNPP2 antibody
  • POMP75 antibody
  • Tls antibody

Protein level used designations for anti-Fused in Sarcoma (FUS) Antibodies

75 kDa DNA-pairing protein , RNA-binding protein FUS , fus-like protein , fusion gene in myxoid liposarcoma , heterogeneous nuclear ribonucleoprotein P2 , oncogene FUS , oncogene TLS , translocated in liposarcoma protein , fusion, derived from t(12;16) malignant liposarcoma , hnRNP P2 , pigpen protein , protein pigpen , translocated in liposarcoma , fusion , pigpen , fusion (involved in t(12;16) in malignant liposarcoma) , 16) in malignant liposarcoma) , 16) malignant liposarcoma , fusion (involved in t(12 , fusion, derived from t(12

GENE ID SPECIES
2521 Homo sapiens
233908 Mus musculus
414144 Gallus gallus
280796 Bos taurus
317385 Rattus norvegicus
479778 Canis lupus familiaris
Selected quality suppliers for anti-FUS (FUS) Antibodies
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