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FUZ encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Additionally we are shipping FUZ Antibodies (10) and FUZ Proteins (5) and many more products for this protein.
Fuzzy appears to control subcellular localization of the core PCP (show BMP1 ELISA Kits) protein Dishevelled (show DVL2 ELISA Kits), recruiting it to Rab8 (show RAB8A ELISA Kits)-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP (show BMP1 ELISA Kits) signaling
Using the ciliopathic Fuz mutant mouse, we find that high arched palate does not, as commonly suggested, arise from midface hypoplasia; rather, increased neural crest expands the maxillary primordia.
The data demonstrate a new model for coordination of Hh and Wnt (show WNT2 ELISA Kits) signaling and reveal a Fuz-dependent negative feedback loop controlling Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.
Fuz plays an important role in cilia formation, Hh signal transduction, and embryonic development in mammals.
This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene.
fuzzy homolog (Drosophila)
, protein fuzzy homolog
, fuzzy homolog