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GPS2 encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. Additionally we are shipping GPS2 Antibodies (49) and GPS2 Proteins (4) and many more products for this protein.
Posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 in vivo.
regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment.
Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 (show MLL2 ELISA Kits) and GPS2 genes, resulting in fusion gene MLL4 (show MLL2 ELISA Kits)-GPS2, the expression of which promotes independent growth.
GPS2 is required for the association of viral NS5A with VAP-A (show VAPA ELISA Kits) and hepatitis C virus replication.
expression of the transcriptional corepressor complex subunits GPS2 and SMRT was significantly reduced in obese adipose tissue, inversely correlated to inflammatory status
Results show for the first time that GPS-2 is differentially methylated at a site that lacks known methylation motifs and that the methylation state is detected by the immune system
metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR (show NCOR1 ELISA Kits) corepressor complex
Results show that the N-CoR (show NCOR1 ELISA Kits)-HDAC3 (show HDAC3 ELISA Kits) complex inhibits JNK (show MAPK8 ELISA Kits) activation through the associated GPS2 subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP-1 (show FOSB ELISA Kits) function.
the GPS2 might function in concert with hMSH4-hMSH5 (show MSH5 ELISA Kits) during the process of homologous recombination.
Direct interactions of GPS2 with hnf4alpha and farnesoid x receptor indicate alternative coregulator recruitment strategies to cause differential transcriptional outcomes in governing bile acid biosynthesis.
GPS2 stabilizes KDM4A (show KDM4A ELISA Kits) on target promoters by inhibiting Ubc13 (show UBE2N ELISA Kits)/RNF8 (show RNF8 ELISA Kits) ubiquitination.
GPS2 binds to active PPARgamma (show PPARG ELISA Kits), facilitates its repression by NCoR (show NCOR1 ELISA Kits), and is required for the optimal NCoR (show NCOR1 ELISA Kits) corepressor function for PPARgamma (show PPARG ELISA Kits).
GPS2 as a molecular guardian required for precise control of inflammatory responses involved in immunity and homeostasis.
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
G protein pathway suppressor 2
, G-protein pathway suppressor 2