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GPS2 encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. Additionally we are shipping GPS2 Antibodies (71) and many more products for this protein.
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our studies identify GPS2 functions as a tumor suppressor in LPS (show IRF6 Proteins) and its downregulation is correlated to prognosis of LPS (show IRF6 Proteins).
Posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 in vivo.
regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment.
Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth.
GPS2 is required for the association of viral NS5A with VAP-A (show VAPA Proteins) and hepatitis C virus replication.
expression of the transcriptional corepressor complex subunits GPS2 and SMRT was significantly reduced in obese adipose tissue, inversely correlated to inflammatory status
Results show for the first time that GPS-2 is differentially methylated at a site that lacks known methylation motifs and that the methylation state is detected by the immune system
metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR (show NCOR1 Proteins) corepressor complex
Results show that the N-CoR (show NCOR1 Proteins)-HDAC3 (show HDAC3 Proteins) complex inhibits JNK (show MAPK8 Proteins) activation through the associated GPS2 subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP-1 (show FOSB Proteins) function.
the GPS2 might function in concert with hMSH4 (show MSH4 Proteins)-hMSH5 (show MSH5 Proteins) during the process of homologous recombination.
GPS2 stabilizes KDM4A (show KDM4A Proteins) on target promoters by inhibiting Ubc13 (show UBE2N Proteins)/RNF8 (show RNF8 Proteins) ubiquitination.
GPS2 binds to active PPARgamma (show PPARG Proteins), facilitates its repression by NCoR (show NCOR1 Proteins), and is required for the optimal NCoR (show NCOR1 Proteins) corepressor function for PPARgamma (show PPARG Proteins).
GPS2 as a molecular guardian required for precise control of inflammatory responses involved in immunity and homeostasis.
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
G protein pathway suppressor 2
, G-protein pathway suppressor 2