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G Protein-Coupled Receptor 119 Proteins (GPR119)

GPR119 encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. Additionally we are shipping G Protein-Coupled Receptor 119 Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPR119 139760 Q8TDV5
Rat GPR119 GPR119 302813 Q7TQN8
GPR119 236781 Q7TQP3
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Top G Protein-Coupled Receptor 119 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details

GPR119 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for G Protein-Coupled Receptor 119 (GPR119) Interaction Partners

Human G Protein-Coupled Receptor 119 (GPR119) interaction partners

  1. Describe novel small-molecule GPR119 agonists with high receptor selectivity and capacity to induce glucose-stimulated insulin (show INS Proteins) secretion.

  2. The GPR119 agonist, HD0471042 increased intracellular cAMP levels in stably human GPR119 expressing CHO cells.

  3. Oxidized-LDL significantly induces lincRNA-DYNLRB2-2 expression, which promotes ABCA1-mediated cholesterol efflux and inhibits inflammation through GPR119 in THP-1 cells.

  4. Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties.

  5. transfection of GLUTag cells with recombinant human GPR119 results in a constitutive and apparently ligand-independent increase of proglucagon (show GCG Proteins) gene promoter activity and proglucagon (show GCG Proteins) mRNA content.

  6. Results provide evidence of an islet-gastrointestinal distribution of GPR119, its expression in pancreatic beta and alpha cells, and its possible involvement in islet function.

  7. Data suggest that GPR119 activation/up-regulation in skeletal muscle impairs fatty acid and glucose oxidation; diet-induced obesity appears to up-regulate skeletal muscle GPR119.

  8. Data show that Phe-V:13 can serve as an aromatic lock for the proposed active conformation of the Trp (show TBPL1 Proteins)-VI:13 rotameric switch, being involved in the global movement of TM-V and TM-VI in 7TM receptor (show CHRM2 Proteins) activation.

  9. findings show that N-oleoyldopamine (OLDA)& structurally related hydroxybenzyl amides are robust activators of GPR119; studies indicate that multiple, distinct classes of lipid amides, acting via GPR119, may be important modulators of glucose homeostasis

  10. GPR119 therefore represents a novel and attractive potential target for the therapy of obesity and related metabolic disorders.

Mouse (Murine) G Protein-Coupled Receptor 119 (GPR119) interaction partners

  1. Data indicate that G-protein coupled receptor 119 (GPR119) knockout prevents the therapeutic effects of Gordonoside F.

  2. Describe novel small-molecule GPR119 agonists with high receptor selectivity and capacity to induce glucose-stimulated insulin (show INS Proteins) secretion.

  3. Novel GPR119 agonist, HD0471042, effectively controlled glucose levels and prevented weight gain in type 2 diabetic mice.

  4. AR231453, a GPR119 agonist, can stimulate beta-cell replication and improve islet graft function

  5. Our results demonstrate that combining a GPR119 agonist with a DPP-IV (show DPP4 Proteins) inhibitor may offer a novel therapeutic strategy for stimulating beta-cell regeneration and reversing diabetes.

  6. Data suggest that GPR119 activation/up-regulation in skeletal muscle impairs fatty acid and glucose oxidation; diet-induced obesity appears to up-regulate skeletal muscle GPR119.

  7. Data suggest that, in lean mice, 2-oleoylglycerol and linoleylethanolamine serve as physiologically relevant endogenous GPR119 agonists that mediate receptor activation upon nutrient uptake.

  8. GPR119 engages multiple complementary pathways for control of glucose homeostasis.

  9. findings show that N-oleoyldopamine (OLDA)& structurally related hydroxybenzyl amides are robust activators of GPR119; studies indicate that multiple, distinct classes of lipid amides, acting via GPR119, may be important modulators of glucose homeostasis

  10. GPR119 therefore represents a novel and attractive potential target for the therapy of obesity and related metabolic disorders.

G Protein-Coupled Receptor 119 (GPR119) Protein Profile

Protein Summary

This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.

Gene names and symbols associated with GPR119

  • G protein-coupled receptor 119 (GPR119)
  • G protein-coupled receptor 119 (LOC100348687)
  • G protein-coupled receptor 119 (Gpr119)
  • G-protein coupled receptor 119 (Gpr119)
  • GPCR2 protein
  • GPR119 protein

Protein level used designations for GPR119

G protein-coupled receptor 119 , G-protein coupled receptor 2 , glucose-dependent insulinotropic receptor , G-protein coupled receptor 119

GENE ID SPECIES
428690 Gallus gallus
446009 Takifugu rubripes
465858 Pan troglodytes
492134 Canis lupus familiaris
524232 Bos taurus
703368 Macaca mulatta
100348687 Oryctolagus cuniculus
139760 Homo sapiens
302813 Rattus norvegicus
236781 Mus musculus
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