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Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Additionally we are shipping GPR124 Kits (1) and and many more products for this protein.
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Human Polyclonal GPR124 Primary Antibody for EIA, IHC (p) - ABIN500895
Vallon, Essler: Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. in The Journal of biological chemistry 2006
Show all 5 references for ABIN500895
Human Polyclonal GPR124 Primary Antibody for IHC, ELISA - ABIN1003260
Carson-Walter, Watkins, Nanda, Vogelstein, Kinzler, St Croix: Cell surface tumor endothelial markers are conserved in mice and humans. in Cancer research 2001
Show all 4 references for ABIN1003260
Human Polyclonal GPR124 Primary Antibody for IHC, ELISA - ABIN1003261
Yamamoto, Irie, Asada, Mino, Mandai, Takai: Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. in Oncogene 2004
Show all 4 references for ABIN1003261
Human Polyclonal GPR124 Primary Antibody for EIA, IHC (p) - ABIN500897
Cross, Lindsey, Fantes, McKay, McGill, Cooke: The structure of a subterminal repeated sequence present on many human chromosomes. in Nucleic acids research 1991
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The GPI (show ITGA2 Antibodies)-anchored MMP inhibitor Reck (show RECK Antibodies) and the adhesion GPCR (show GPRC6A Antibodies) Gpr124 are integral components of the Wnt7a (show WNT7A Antibodies)/Wnt7b (show WNT7B Antibodies)-specific signaling complex required for brain angiogenesis and dorsal root ganglia neurogenesis.
Observed an inverse correlation between the expression of miR (show MLXIP Antibodies)-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR (show MLXIP Antibodies)-138-5p on the sensitivity to gefitinib.
Thrombin (show F2 Antibodies)-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein (show CD28 Antibodies) disulfide-isomerase (show P4HB Antibodies).
TEM5 expression during capillary morphogenesis is induced by the small GTPase (show RACGAP1 Antibodies) Rac (show AKT1 Antibodies) and mediates contact inhibition of proliferation in endothelial cells.
Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v (show ITGAV Antibodies))beta3 to glycosaminoglycans
Vital role for GPR124 is potentiation of WNT7 (show WNT7B Antibodies)-induced canonical beta-catenin (show CTNNB1 Antibodies) signaling with important implications for understanding and manipulating CNS-specific angiogenesis.
Gpr124 functions as coactivator of Wnt7a (show WNT7A Antibodies)- and Wnt7b (show WNT7B Antibodies)-stimulated canonical Wnt (show WNT2 Antibodies) signaling via Frizzled receptor and Lrp (show LRP1 Antibodies) coreceptor and that Gpr124-stimulated signaling functions in concert with Norrin (show NDP Antibodies)/Frizzled4 (show FZD4 Antibodies) signaling to control CNS vascular development
GPR124, an orphan G protein-coupled receptor (show GPRC5C Antibodies), is required for CNS-specific vascularization and establishment of the blood-brain barrier.
TGF-beta (show TGFB1 Antibodies) stimulates Gpr124 expression which is required for angiogenic sprouting into neural tissues.
study shows that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube; results demonstrate CNS-specific angiogenesis regulation by an endothelial receptor
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube.
G protein-coupled receptor 124
, probable G-protein coupled receptor 124-like
, G-protein coupled receptor 124
, tumor endothelial marker 5