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GPR126, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Additionally we are shipping G Protein-Coupled Receptor 126 Antibodies (52) and G Protein-Coupled Receptor 126 Proteins (5) and many more products for this protein.
A new zebrafish mutation that truncates Gpr126 disrupted development of peripheral nerves and the inner ear.
GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling
a model in which the NTF (show TNF ELISA Kits) of Gpr126, in contrast to the C-terminal fragment, plays an important role in heart development.
Gpr126 acts through a cAMP-mediated pathway to control the outgrowth and adhesion of canal projections in the zebrafish ear via the regulation of extracellular matrix gene expression.
gpr126 mutant Schwann cells elaborate mature myelin sheaths and maintain krox20 (show EGR2 ELISA Kits) expression for months, provided that the early signaling defect is bypassed by transient elevation of cAMP.
study found that Gpr126 is required autonomously in Schwann cells for myelination; propose that Gpr126 drives the differentiation of promyelinating Schwann cells by elevating cAMP levels, thereby triggering Oct6 expression and myelination
Together, these data uncover Gpr126 as a genetic cause for the pathogenesis of Adolescent idiopathic scoliosis (AIS (show AR ELISA Kits)) and pectus excavatum in a mouse model.
Genetic variants of GPR126 gene are associated with adolescent idiopathic scoliosis susceptibility in Chinese populations.
Mutations of GPR126 are responsible for severe arthrogryposis multiplex congenita.
Gpr126 functions in Schwann cells for proper development and myelination through G-protein-signaling pathways.
A single nucleotide polymorphism in the GPR126 gene is associated with increased susceptibility for adolescent idiopathic scoliosis. [Meta-analysis]
Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms.
The PS1TP2 gene was located at 6q24.1, and interacts with leukocyte proteins.
VIGR represents a novel G protein coupled receptors of the adhesion family, which is unique in its long extra-cellular domain.
APG1 (show HSPA4L ELISA Kits) formed an alpha-helical structure at the C-terminal site and a positive charge cluster at the N-terminal site.
PrP(C (show PRNP ELISA Kits)) promotes myelin homeostasis through flexible tail-mediated Gpr126 agonism
Analysis shows that Gpr126 is required for Schwann cell myelination in mammals, and defines new roles for Gpr126 in axonal sorting, formation of mature non-myelinating Schwann cells and organization of the perineurium.
Data show that GPR126 is required for embryonic viability and cardiovascular development.
This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene.
G-protein coupled receptor 126
, G protein-coupled receptor 126
, unm st49
, G-protein coupled receptor 126-like
, HBV PreS1-transactivated protein 2
, developmentally regulated G-protein-coupled receptor
, vascular inducible G protein-coupled receptor
, vascular-inducible G protein-coupled receptor
, probable G-protein coupled receptor 126