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G Protein-Coupled Receptor 143 Proteins (GPR143)

GPR143 encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. Additionally we are shipping G Protein-Coupled Receptor 143 Antibodies (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPR143 4935 P51810
GPR143 18241 P70259
Rat GPR143 GPR143 302619  
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Top G Protein-Coupled Receptor 143 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
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GPR143 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for G Protein-Coupled Receptor 143 (GPR143) Interaction Partners

Human G Protein-Coupled Receptor 143 (GPR143) interaction partners

  1. Downstream signaling from GPR143 controls RPE (show RPE Proteins) secretion of pigment epithelium-derived factor (PEDF (show SERPINF1 Proteins)), a potent neurotrophic and antiangiogenic factor.

  2. Five mutations in GPR143 gene were detected in each of the five families, including a novel nonsense mutation of c.333G>A,two novel splicing mutations of c.360+1G>C and c.659-1G>A, a novel small deletion mutation of c.43_50dupGACGCAGC.

  3. intronic mutation that creates a cryptic splice-donor site in GPR143 of patients with ocular albinism

  4. The GPR143 gene analysis identified an identical point mutation in two Ocular albinism 1 patients and their mothers .

  5. Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL (show PMEL Proteins) expression.

  6. OA1 is involved in melanoma cell migration and that OA1induced melanoma cell migration is mediated through the RAS/RAF (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling pathway.

  7. a novel splicing site mutation of the GPR143 gene was found in a Han Chinese congenital ocular albinism pedigree.

  8. Data report that p.Y269X mutation of GPR143 gene is responsible for the pathogenesis of familial ocular albinism.

  9. These results identify the Oa1 transducer Galphai3 (show GNAI3 Proteins) as the first downstream component in the Oa1 signaling pathway.

  10. The ocular albinism type 1 (OA1) GPCR is ubiquitinated and its traffic requires endosomal sorting complex responsible for transport (ESCRT) function.

Mouse (Murine) G Protein-Coupled Receptor 143 (GPR143) interaction partners

  1. OA1 expression in both neuronal and non-neuronal tissues was examined by immunohistochemical analyses, results suggested that OA1 may modulate the monoaminergic functions in both peripheral and central nervous systems

  2. Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL (show PMEL Proteins) expression.

  3. These results identify the Oa1 transducer Galphai3 (show GNAI3 Proteins) as the first downstream component in the Oa1 signaling pathway.

  4. OA1 interacts with MART-1 at early stages of melanogenesis to control melanosome identity and composition.

  5. Asparagine at amino acid 106 is essential for N-glycosylation of the Oa1 protein. Mutation at amino acid 106 that eliminated glycosylation did not affect the endo/lysosomal distribution of Oa1 protein in cells.

  6. the ocular albinism type 1 gene expression is controlled by microphthalmia transcription factor (Mitf (show MITF Proteins))

  7. The findings indicate that Oa1 is involved in the regulation of melanosome maturation at two steps, Oa1 controls the abundance of melanosomes in RPE (show RPE Proteins) cells and has a function in the maintenance of a correct melanosomal size.

  8. G alpha i3, like Oa1, plays important role in melanosome biogenesis. Common Oa1-G alpha i3 signaling pathway may ultimately affect axonal growth through optic chiasm.

  9. data point to defective regulation of organelle transport in pigment cells in absence of OA1; results enlighten novel function for OA1 in pigment cells & suggest ocular albinism type 1 may result from a different mechanism than previously thought

G Protein-Coupled Receptor 143 (GPR143) Protein Profile

Protein Summary

This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y.

Gene names and symbols associated with GPR143

  • G protein-coupled receptor 143 (GPR143)
  • G protein-coupled receptor 143 (Gpr143)
  • NYS6 protein
  • Oa1 protein
  • RGD1565799 protein

Protein level used designations for GPR143

G-protein coupled receptor 143 , ocular albinism type 1 protein , MOA1 , homolog of human ocular albinism 1 (Nettleship-Falls) , ocular albinism type 1 protein homolog

GENE ID SPECIES
4935 Homo sapiens
18241 Mus musculus
302619 Rattus norvegicus
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