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Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Additionally we are shipping GPR17 Proteins (4) and many more products for this protein.
Showing 10 out of 94 products:
Human Polyclonal GPR17 Primary Antibody for ELISA, WB - ABIN4315679
Parravicini, Ranghino, Abbracchio, Fantucci: GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. in BMC bioinformatics 2008
GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.
This review summarizes knowledge about role of GPR17 receptors in physiology and pathology of nervous system, with special attention to remyelination processes.
Low levels of GRK2 (show ADRBK1 Antibodies)/GRK5 (show GRK5 Antibodies) causes a slow and not complete desensitization/down-regulation of GPR17.
Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor (show GPRC5D Antibodies) GPR17.
Data validate GPR17 as a target for neurorepair
Nucleotides, nucleotide sugars, and cysteinyl leukotrienes do not promote activation of GPR17 in five different cell lines, nor does GPR17 have signaling properties.
analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells
A functional cross-talk exists between cysteinyl-leukotriene and purinergic sites at GPR17; the latter have a hierarchy in producing desensitizing signals.
We present the first isoform-specific characterization of GPR17 and show that differences exist between the isoforms in expression pattern and pharmacological profile; the two human isoforms might serve tissue-specific functions
GPR17, a Gi-coupled orphan receptor (show NR1D2 Antibodies) at intermediate phylogenetic position between P2Y (show P2RY1 Antibodies) and CysLT receptors, is specifically activated by both families of endogenous ligands.
GPR17(+) cells--in contrast to GPR17(-) NG2 (show Vcan Antibodies)-glia--did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia
stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (show MBP Antibodies) expression levels mainly by triggering the Galphai/o signaling pathway.
Agrp (show AGRP Antibodies)-Gpr17(-/-) mice show reduced food intake, increased relative energy expenditure, and increased satiety, resulting in leanness and reduced body fat. They also show increased central nervous system sensitivity to insulin (show INS Antibodies) and leptin (show LEP Antibodies).
The mouse GPR17 receptor plays a central role in the early response of cardiac stromal cells to ischaemia.
Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor (show GPRC5C Antibodies) GPR17.
GPR17 is a marker for progenitor progression within the oligodendroglial lineage that participates in postacute reactivity of NG2 (show Vcan Antibodies)-proteoglycan (show Vcan Antibodies) expressing cells in different injury paradigms.
CysLT1R (show CYSLTR1 Antibodies), CysLT2R (show CYSLTR2 Antibodies) and GPR17 might be involved in the MPTP (show PTPN2 Antibodies)-induced Parkinson disease damage in mice.
Study finds that transcription factor FoxO1 (show FOXO1 Antibodies) exerts integrative control of leptin (show LEP Antibodies), insulin (show INS Antibodies), and amino acid signaling in AgRP (show AGRP Antibodies) neurons, effectively coordinating food intake with peripheral metabolism; and identifies of a heretofore unrecognized FoxO1 (show FOXO1 Antibodies) pathway that regulates food intake through the G protein-coupled receptor (show GPR34 Antibodies), Gpr17.
GPR17 is expressed by a subpopulation of oligodendrocyte precursor cells, but not by astrocytes; this expression pattern is also confirmed in vivo. In vitro, GPR17 expression is markedly influenced by culturing conditions.
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
G protein-coupled receptor 17
, uracil nucleotide/cysteinyl leukotriene receptor-like
, uracil nucleotide/cysteinyl leukotriene receptor
, G-protein coupled receptor 17
, P2Y-like receptor
, UDP/CysLT receptor