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Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Additionally we are shipping GPR3 Antibodies (107) and GPR3 Kits (1) and many more products for this protein.
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Gpr3 stimulates Abeta (show APP Proteins) production via interactions with APP (show APP Proteins) and beta-arrestin2 (show ARRB2 Proteins).
GPR3 is a key factor in the regulation of the nervous system and follicle development.[review]
GPR3 is expressed in the ovary and testes, and is necessary for the regulation of meiosis in mouse.
Mutations in GPR3 are not a common cause of premature ovarian failure in Chinese women.
We conclude that perturbations in GPR3 are not a common explanation for POF (show POF1B Proteins) in this population.
GPR3 appears to have a key role in the thermogenic response of interscapular brown adipose tissue and may represent a new therapeutic target in age-related obesity.
This study found that the expression of GPR3 in CGNs exerted prosurvival effects against apoptosis-inducing stimuli, such as potassium deprivation, hypoxia, and ROS (show ROS1 Proteins).
Altered signalling pathways of GPR3 could contribute to the neurobiological substrate involved in developing addiction to cocaine
Involvement of the orphan GPR3 receptor is demonstrated for the first time in expression and development of neuropathic pain and in analgesia induced by morphine.
the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis
Gpr3-defective mice may constitute a relevant model of premature ovarian failure due to early oocyte aging.
the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12 (show GPR12 Proteins)
GPR3 specifically in the oocyte, rather than in the follicle cells, is responsible for maintenance of meiotic arrest in mouse oocytes.
GPR3-G(s) activation in response to stimulation of an exogenously expressed beta(2)-adrenergic receptor (show ADRB2 Proteins) causes Galpha (show SUCLG1 Proteins)(s) to move from the oocyte plasma membrane into the cytoplasm.
Gpr3 is epistatic to Pde3a (show PDE3A Proteins) and fertility as well as meiotic arrest in the PDE3A (show PDE3A Proteins)-deficient oocyte is dependent on the activity of GPR3.
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
G protein-coupled receptor 3
, ACCA orphan receptor
, G-protein coupled receptor 3
, adenylate cyclase constitutive activator
, G protein-coupled receptor R4
, G-protein-coupled receptor R4