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G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). Additionally we are shipping GPR34 Antibodies (75) and many more products for this protein.
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By monitoring fused FLAG-tag and conformation-sensitive native epitope during expression of GPR34 mutants, a tri (show VANGL2 Proteins)-basic motif in the first intracellular loop was identified as key topogenic signal that dictates the orientation of transmembrane domain-1.
GPR34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro and provides a potential implication for therapy of gastric cancer.
up-regulation of GPR34 expression in human gastric carcinoma may play a critical role in tumor progression and in determining patient prognosis
The present studies confirm that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position.
these results are the first to identify a role for a GPR34 in lymphoma cell growth, provide insight into GPR34-mediated signaling, identify a genetically unique subset of MZLs that express high levels of GPR34.
data show that multiple translation initiation starts and alternative splicing contribute to the supragenomic diversification of GPR34
Our study reveals a novel role of GPR34 in the fate of dendritic cells
GPR34-deficient microglia showed reduced phagocytosis activity in both retina and acutely isolated cortical slices.
GPR34-deficient mice showed significantly increased paw swelling in the delayed type hypersensitivity test and higher pathogen burden in extrapulmonary tissues after pulmonary infection with Cryptococcus neoformans compared with wild-type mice.
G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.
G protein-coupled receptor 34
, G-protein-coupled receptor GPR34
, probable G-protein coupled receptor 34
, G-protein-coupled receptor