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G Protein-Coupled Receptor 4 Proteins (GPR4)

Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.. Additionally we are shipping GPR4 Antibodies (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPR4 2828 P46093
GPR4 319197 Q8BUD0
Rat GPR4 GPR4 308408 Q4KLH9
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Top GPR4 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days

GPR4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for G Protein-Coupled Receptor 4 (GPR4) Interaction Partners

Human G Protein-Coupled Receptor 4 (GPR4) interaction partners

  1. GPR4 induces angiogenesis via GPR4-induced p38 (show CRK Proteins)-mediated IL6 (show IL6 Proteins), IL8 (show IL8 Proteins) and VEGFA (show VEGFA Proteins) secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck

  2. The results suggested that GPR4 may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC

  3. acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac (show RAPGEF3 Proteins) pathway

  4. The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation.

  5. Endogenous GPR4 in endothelial cells may be a potential G protein-coupled receptor (show ADRA1A Proteins) by which LPC (show PCSK7 Proteins) signals proinflammatory activities.

  6. GPR4, a close relative of OGR1, also responds to pH changes, but elicits cyclic AMP (show APRT Proteins) formation

  7. sphingosylphosphorylcholine and lysophosphatidic acid are not the ligands for GPR4 and that this receptor may constitutively inhibit ERK1/2 activation

  8. GPR4 and TDAG8 (show GPR65 Proteins) overexpression in human tumors plays a role in driving or maintaining tumor formation

  9. results identify sphingosylphosphorylcholine and its receptor, G protein-coupled receptor 4(GPR4), as critical regulators of the angiogenic potential of endothelial cells

  10. GPR4 may play a critical role in the inflammatory responses activated by lysophosphatidylcholine

Mouse (Murine) G Protein-Coupled Receptor 4 (GPR4) interaction partners

  1. knockdown of a proton-sensing G protein-coupled receptor (show GPR34 Proteins) GPR4 markedly reduced CHOP (show DDIT3 Proteins) expression and endothelial cell apoptosis after hypoxia exposure.

  2. The results indicate that through the G12 (show TCF3 Proteins)/13/Rho signaling pathway GPR4 modulates focal adhesion dynamics and reduces cell spreading and membrane ruffling.

  3. The data identify GPR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.

  4. These results suggested that, at least in part, RANKL (show TNFSF11 Proteins) expression by osteoblasts in an acidic environment was mediated by cAMP/PKA signaling resulting from GPR4 activation.

  5. GPR4 modulates glucose homeostasis by increasing insulin (show INS Proteins) sensitivity.

  6. Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.

  7. findings suggest that GPR4 activation by an acidic pH inhibits tumor cell migration and invasion, and the Rho GTPase (show RACGAP1 Proteins) is at least partly responsible for this phenotype

  8. These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing.

GPR4 Protein Profile

Protein Summary

Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.

Gene names and symbols associated with GPR4

  • G protein-coupled receptor 4 (GPR4)
  • G protein-coupled receptor 4 (Gpr4)

Protein level used designations for GPR4

G-protein coupled receptor 19 , G-protein coupled receptor 4

2828 Homo sapiens
319197 Mus musculus
308408 Rattus norvegicus
512876 Bos taurus
100144489 Sus scrofa
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