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GPR50 product belongs to the G-protein coupled receptor 1 family. Additionally we are shipping GPR50 Antibodies (69) and GPR50 Proteins (6) and many more products for this protein.
The results provide deeper insight into the functional evolution of GPR50 in mammals at the molecular level
There was only weak female-specific association between GPR50 variants in late-life depression. No significant associations were observed in men.
study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 in females.
we found 2 polymorphisms in the GPR50 receptor of patients with adolescent idiopathic scoliosis, but they were not present at a highly significant frequency when compared with controls
Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH (show DST ELISA Kits)) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus.
This is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus.
Results identify neurite outgrowth inhibitor NOGO-A (show RTN4 ELISA Kits) as an interacting partner of GPR50 and found an enrichment of both Gpr50 and neuronal Nogo-A (show RTN4 ELISA Kits) at the synapse.
Polymorphisms in GPR50 were compared in bipolar affective disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ) and controls. GPR50(Delta502-505) or a variant is a sex-specific risk factor for susceptibility to BD and SCZ.
Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL (show HSD11B1 ELISA Kits) levels.
GPR50, an orphan GPCR (show NMUR1 ELISA Kits), heterodimerizes constitutively and specifically with MT(1 (show MT1A ELISA Kits)) and MT(2 (show MT2 ELISA Kits)) melatonin receptors
GPR50 promotes neuronal differentiation through its intracellular domain.
A link is identified between GPR50 expression and neurotransmitter signaling during brain development.
Data indicate that Txnip (show TXNIP ELISA Kits) expression is increased in the hypothalamus of Gpr50-/- mice during torpor.
GPR50 is a component of adaptive thermogenesis in mice
An enlarged distribution of GPR50 protein in the brain.
Data demonstrate that GPR50 can enhance TIP60 (show KAT5 ELISA Kits)-coactiavtion of glucocorticoid receptor (GR (show NR3C1 ELISA Kits)) signalling.
GPR50 is an important regulator of energy metabolism
This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women.
G protein-coupled receptor 50
, melatonin-related receptor
, g protein-coupled receptor 50