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G Protein-Coupled Receptor 50 Proteins (GPR50)

GPR50 product belongs to the G-protein coupled receptor 1 family. Additionally we are shipping GPR50 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPR50 9248 Q13585
Rat GPR50 GPR50 117097  
GPR50 14765 O88495
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Top GPR50 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
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GPR50 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for G Protein-Coupled Receptor 50 (GPR50) Interaction Partners

Human G Protein-Coupled Receptor 50 (GPR50) interaction partners

  1. The results provide deeper insight into the functional evolution of GPR50 in mammals at the molecular level

  2. There was only weak female-specific association between GPR50 variants in late-life depression. No significant associations were observed in men.

  3. study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 in females.

  4. we found 2 polymorphisms in the GPR50 receptor of patients with adolescent idiopathic scoliosis, but they were not present at a highly significant frequency when compared with controls

  5. Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH (show DST Proteins)) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus.

  6. This is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus.

  7. Results identify neurite outgrowth inhibitor NOGO-A (show RTN4 Proteins) as an interacting partner of GPR50 and found an enrichment of both Gpr50 and neuronal Nogo-A (show RTN4 Proteins) at the synapse.

  8. Polymorphisms in GPR50 were compared in bipolar affective disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ) and controls. GPR50(Delta502-505) or a variant is a sex-specific risk factor for susceptibility to BD and SCZ.

  9. Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL (show HSD11B1 Proteins) levels.

  10. GPR50, an orphan GPCR (show NMUR1 Proteins), heterodimerizes constitutively and specifically with MT(1 (show MT1A Proteins)) and MT(2 (show MT2 Proteins)) melatonin receptors

Mouse (Murine) G Protein-Coupled Receptor 50 (GPR50) interaction partners

  1. GPR50 promotes neuronal differentiation through its intracellular domain.

  2. A link is identified between GPR50 expression and neurotransmitter signaling during brain development.

  3. Data indicate that Txnip (show TXNIP Proteins) expression is increased in the hypothalamus of Gpr50-/- mice during torpor.

  4. GPR50 is a component of adaptive thermogenesis in mice

  5. An enlarged distribution of GPR50 protein in the brain.

  6. Data demonstrate that GPR50 can enhance TIP60 (show KAT5 Proteins)-coactiavtion of glucocorticoid receptor (GR (show NR3C1 Proteins)) signalling.

  7. Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH (show DST Proteins)) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus.

  8. GPR50 is an important regulator of energy metabolism

GPR50 Protein Profile

Protein Summary

This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women.

Gene names and symbols associated with GPR50

  • G protein-coupled receptor 50 (GPR50)
  • G protein-coupled receptor 50 (Gpr50)
  • G-protein-coupled receptor 50 (Gpr50)
  • H9 protein
  • Mel1c protein

Protein level used designations for GPR50

G protein-coupled receptor 50 , melatonin-related receptor , g protein-coupled receptor 50

GENE ID SPECIES
492213 Canis lupus familiaris
530065 Bos taurus
736267 Pan troglodytes
9248 Homo sapiens
117097 Rattus norvegicus
443023 Ovis aries
14765 Mus musculus
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