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Members of the G protein-coupled receptor (GPR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell (Sawzdargo et al., 1999 [PubMed 9931487]).[supplied by OMIM, Apr 2008].. Additionally we are shipping GPR55 Antibodies (36) and GPR55 Kits (1) and many more products for this protein.
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Inhibiting the pro-angiogenic L-alpha-lysophosphatidylinositol /GPR55 pathway appears a promising target against angiogenesis in ovarian carcinoma
GPR55 is expressed in placenta,located solely at the placental endothelium; L-alpha-lysophosphatidylinositol (LPI (show Slc7a7 Proteins)), the endogenous ligand of GPR55, increases migratory activity of venous but not arterial placental endothelial cells suggesting a role of LPI (show Slc7a7 Proteins)-GPR55 axis in placental venous endothelium function
GPR55 could play deleterious role in ox-LDL-induced foam cells and could be a novel pharmacological target to manage atherosclerosis and other related cardiovascular diseases.
GPR55 was a direct target gene of miR (show MLXIP Proteins)-675-5p.
expression of CB1 (show CNR1 Proteins) and GPR55 in proximal tubules is altered in response to elevated levels of glucose and albumin (show ALB Proteins)
This review summarizes our current knowledge of expression and function of GPR55 in tissues involved in metabolic regulation and the signaling cascades through which GPR55 is reported to act.
Heteromerization of GPR55 and cannabinoid CB2 (show CNR2 Proteins) receptors modulates signalling
Data suggest GPR55 (G-protein coupled receptor 55), ABCC1 (show ABCC1 Proteins) (ATP-binding cassette sub-family C), and MPR1 (show IGF2R Proteins)/ABCB1 (multidrug resistance protein 1 (show ABCB1 Proteins)) participate/cooperate in autocrine communication/tumorigenesis involving lysophosphatidylinositol. [REVIEW]
CB2R (show CNR2 Proteins) and GPR55 form heteromers in cancer cells, these structures possess unique signaling properties, and modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo
GPR55 receptors were expressed in urothelial cell lines and interact with CB1 (show CNR1 Proteins) receptors.
Results indicate that GPR55 modulates the growth rate and the targets innervation of retinal projections and highlight, for the first time, an important role of GPR55 in axon refinement during development
Data show evidence of GPR55 involvement in central pain processing and unravel a novel Ca2 (show CA2 Proteins)+-mediated mechanism by which periaqueductal gray neurons are activated downstream of GPR55.
Mice deficient in GPR55 exhibit maladaptive adrenergic signalling, as evidenced by the reduced contractile reserve.
GPR55 is distributed in pancreatic beta cells and is a strong activator of insulin (show INS Proteins) secretion, with glucose-lowering effects in vivo. Development of agents agonizing the GPR55 receptor may have therapeutic potential in the treatment of type 2 diabetes.
Data (including data from knockout mice) suggest that GPR55 is strongly expressed on myenteric neurons of the colon and that GPR55 is selectively involved in the regulation of colonic motility.
GPR55 plays a role in motor coordination, but does not strongly regulate CNS development, gross motor movement or several types of learned behavior.
GPR55 drives mouse skin tumor development.
Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses.
Data show that G protein-coupled receptor 55 exists throughout the intestines of rats, and that O-1602 or CBD (show OPN1MW Proteins) selectively normalized motility disturbances due to inflammation.
Members of the G protein-coupled receptor (GPR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell (Sawzdargo et al., 1999
G protein-coupled receptor 55
, G-protein coupled receptor 55