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anti-G Protein-Coupled Receptor 65 (GPR65) Antibodies

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Additionally we are shipping GPR65 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GPR65 8477 Q8IYL9
GPR65 14744 Q61038
GPR65 299242  
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Top anti-GPR65 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of GPR65 (arrow) in Hela cell line lysates (35ug/lane) using GPR65 / Psychosine receptor  0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of GPR65 Antibody (C-term) (ABIN653454) in Hela cell line lysates (35 µg/lane). GPR65 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of Tonsil using anti- GPR65 antibody ABIN122422 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon cancer labeled with Anti-GPR65 Polyclonal Antibody, Unconjugated (ABIN872800) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. Formalin-fixed and paraffin embedded human colon cancer labeled with Anti-GPR65 Polyclonal Antibody, Unconjugated (ABIN872800) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C and DAPI staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p) Anti-GPR65 antibody  ABIN1048858 IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-GPR65 antibody  ABIN1048859 IHC staining of human lymph node, hodgkin's disease. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of Lymph node (Hodgkin's disease) using anti- GPR65 antibody ABIN122423 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p) Anti-GPR65 antibody  ABIN1048860 IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated ELISA, WB   50 μg Log in to see 9 to 11 Days
$742.00
Details

GPR65 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GPR65 Antibodies

  1. Human Monoclonal GPR65 Primary Antibody for ELISA, WB - ABIN335188 : Wang, Kon, Mogi, Tobo, Damirin, Sato, Komachi, Malchinkhuu, Murata, Kimura, Kuwabara, Wakamatsu, Koizumi, Uede, Tsujimoto, Kurose, Sato, Harada, Misawa, Tomura, Okajima: TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for ABIN335188

  2. Human Polyclonal GPR65 Primary Antibody for EIA, WB - ABIN952613 : Mogi, Tobo, Tomura, Murata, He, Sato, Kimura, Ishizuka, Sasaki, Sato, Kihara, Ishii, Harada, Okajima: Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 3 references for ABIN952613

More Antibodies against GPR65 Interaction Partners

Human G Protein-Coupled Receptor 65 (GPR65) interaction partners

  1. TDAG8 expression is decreased by more than 50%.

  2. GPR65 is a regulator upstream of MMP3, which is regulated by proton-sensing G-protein-coupled receptors

  3. Acidosis promotes Bcl-2 (show BCL2 Antibodies) family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor (show ADRA1A Antibodies) Gpr65 signaling to Mek (show MAP2K1 Antibodies)/Erk (show EPHB2 Antibodies).

  4. Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes and macrophages.

  5. These results support the hypothesis that TDAG8 enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation.

  6. GPR4 (show GPR4 Antibodies) and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation

  7. TDAG8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4 (show GPR4 Antibodies), and OGR1 (show GPR68 Antibodies).

  8. TDAG8 may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis.

  9. Expression of TDAG8 by immune cells may regulate responses in acidic microenvironments.

  10. At least partly, TDGA8 mediates extracellular acidification-induced inhibition of proinflammatory cytokine production through the Gs protein/cyclic AMP (show APRT Antibodies)-dependent protein kinase A signaling pathway in transgenic mouse macrophages.

Mouse (Murine) G Protein-Coupled Receptor 65 (GPR65) interaction partners

  1. TDAG8 is a negative regulator for lung neutrophilic inflammation and injury, in part, through the inhibition of chemokine (show CCL1 Antibodies) production.

  2. TDAG8(-/-) mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes.

  3. The results of this study indicated that the proton-sensing G protein-coupled receptor (show GPR34 Antibodies) GPR65 may be involved in a mechanism that supports survival of photoreceptors in the degenerating retina.

  4. This study demonstrates differential regulation of eosinophils and mast cells in inflammatory tissue, with mast cell viability and accumulation being independent of GPR65.

  5. IL-1beta (show IL1B Antibodies) mRNA and protein were attenuated in microglia from TDAG8-deficient mice. TDAG8/PKA signaling inhibits LPS (show TLR4 Antibodies)-induced ERK (show EPHB2 Antibodies) and JNK (show MAPK8 Antibodies). This inhibits IL-1beta (show IL1B Antibodies) production. TDAG8 may mediate the proton-induced inhibition of LPS (show TLR4 Antibodies)-induced cytokine production.

  6. Results suggest that the enhancement of TDAG8 function represents a new strategy for preventing bone resorption diseases, such as osteoporosis.

  7. Acidosis promotes Bcl-2 (show BCL2 Antibodies) family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor (show GPR34 Antibodies) Gpr65 signaling to Mek (show MDK Antibodies)/Erk (show EPHB2 Antibodies).

  8. Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes, macrophages, and splenocytes.

  9. TDAG8 is involved in the GC-induced anti-inflammatory actions in macrophages.

  10. TDAG8 acts as a negative regulator of inflammation

GPR65 Antigen Profile

Protein Summary

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells.

Gene names and symbols associated with GPR65

  • G protein-coupled receptor 65 (GPR65) antibody
  • G protein-coupled receptor 65 (gpr65) antibody
  • G protein-coupled receptor 65 (LOC100352288) antibody
  • G-protein coupled receptor 65 (Gpr65) antibody
  • Dig1 antibody
  • Gpcr25 antibody
  • hTDAG8 antibody
  • Tdag8 antibody

Protein level used designations for GPR65

G protein-coupled receptor 65 , psychosine receptor , G-protein coupled receptor 65 , T-cell death-associated gene 8 protein , G-protein coupled receptor 25 , T cell death associated protein 8

GENE ID SPECIES
423395 Gallus gallus
693449 Macaca mulatta
788507 Bos taurus
100135008 Xenopus (Silurana) tropicalis
100352288 Oryctolagus cuniculus
100587919 Nomascus leucogenys
8477 Homo sapiens
490821 Canis lupus familiaris
467610 Pan troglodytes
14744 Mus musculus
299242 Rattus norvegicus
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