You are viewing an incomplete version of our website. Please click to reload the website as full version.

G Protein-Coupled Receptor 65 Proteins (GPR65)

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Additionally we are shipping GPR65 Antibodies (56) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPR65 8477 Q8IYL9
GPR65 14744 Q61038
Rat GPR65 GPR65 299242  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top GPR65 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

GPR65 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for G Protein-Coupled Receptor 65 (GPR65) Interaction Partners

Human G Protein-Coupled Receptor 65 (GPR65) interaction partners

  1. TDAG8 expression is decreased by more than 50%.

  2. GPR65 is a regulator upstream of MMP3, which is regulated by proton-sensing G-protein-coupled receptors

  3. Acidosis promotes Bcl-2 (show BCL2 Proteins) family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor (show ADRA1A Proteins) Gpr65 signaling to Mek (show MAP2K1 Proteins)/Erk (show EPHB2 Proteins).

  4. Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes and macrophages.

  5. These results support the hypothesis that TDAG8 enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation.

  6. GPR4 (show GPR4 Proteins) and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation

  7. TDAG8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4, and OGR1.

  8. TDAG8 may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis.

  9. Expression of TDAG8 by immune cells may regulate responses in acidic microenvironments.

  10. At least partly, TDGA8 mediates extracellular acidification-induced inhibition of proinflammatory cytokine production through the Gs protein/cyclic AMP (show APRT Proteins)-dependent protein kinase A signaling pathway in transgenic mouse macrophages.

Mouse (Murine) G Protein-Coupled Receptor 65 (GPR65) interaction partners

  1. TDAG8 is a negative regulator for lung neutrophilic inflammation and injury, in part, through the inhibition of chemokine (show CCL1 Proteins) production.

  2. TDAG8(-/-) mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes.

  3. The results of this study indicated that the proton-sensing G protein-coupled receptor (show GPR34 Proteins) GPR65 may be involved in a mechanism that supports survival of photoreceptors in the degenerating retina.

  4. This study demonstrates differential regulation of eosinophils and mast cells in inflammatory tissue, with mast cell viability and accumulation being independent of GPR65.

  5. IL-1beta (show IL1B Proteins) mRNA and protein were attenuated in microglia from TDAG8-deficient mice. TDAG8/PKA signaling inhibits LPS (show TLR4 Proteins)-induced ERK (show EPHB2 Proteins) and JNK (show MAPK8 Proteins). This inhibits IL-1beta (show IL1B Proteins) production. TDAG8 may mediate the proton-induced inhibition of LPS (show TLR4 Proteins)-induced cytokine production.

  6. Results suggest that the enhancement of TDAG8 function represents a new strategy for preventing bone resorption diseases, such as osteoporosis.

  7. Acidosis promotes Bcl-2 (show BCL2 Proteins) family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor (show GPR34 Proteins) Gpr65 signaling to Mek (show MDK Proteins)/Erk (show EPHB2 Proteins).

  8. Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes, macrophages, and splenocytes.

  9. TDAG8 is involved in the GC-induced anti-inflammatory actions in macrophages.

  10. TDAG8 acts as a negative regulator of inflammation

GPR65 Protein Profile

Protein Summary

Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells.

Gene names and symbols associated with GPR65

  • G protein-coupled receptor 65 (GPR65)
  • G protein-coupled receptor 65 (gpr65)
  • G protein-coupled receptor 65 (LOC100352288)
  • G-protein coupled receptor 65 (Gpr65)
  • Dig1 protein
  • Gpcr25 protein
  • hTDAG8 protein
  • Tdag8 protein

Protein level used designations for GPR65

G protein-coupled receptor 65 , psychosine receptor , G-protein coupled receptor 65 , T-cell death-associated gene 8 protein , G-protein coupled receptor 25 , T cell death associated protein 8

GENE ID SPECIES
423395 Gallus gallus
693449 Macaca mulatta
788507 Bos taurus
100135008 Xenopus (Silurana) tropicalis
100352288 Oryctolagus cuniculus
100587919 Nomascus leucogenys
8477 Homo sapiens
490821 Canis lupus familiaris
467610 Pan troglodytes
14744 Mus musculus
299242 Rattus norvegicus
Selected quality suppliers for GPR65 Proteins (GPR65)
Did you look for something else?