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Proton-sensing receptor involved in pH homeostasis. Additionally we are shipping GPR68 Antibodies (69) and and many more products for this protein.
The deconstruction of OGR1-dependent signaling may aid our understanding of mucosal inflammation mechanisms
Provide evidence for the roles of OGR1 and ASIC1a (show ACCN2 ELISA Kits) in the regulation of intestinal passive Mg(2 (show MUC7 ELISA Kits)+) absorption.
the expression of OGR1 in myeloid-derived cells, especially in double positive cells, was required for prostate tumor cell-induced immunosuppression.
The involvement of ovarian cancer G-protein-coupled receptor 1 in acidic extracellular environment may be an underlying mechanism responsible for bone pain in osteoporosis or bone metastasis without clinically proved fractures.
OGR1 activation increased intracellular calcium in transfe (show ATP6AP1 ELISA Kits)cted HEK293 cells.
It indicated that OGR1 may be a tumor suppressor gene for ovarian cancer.
extracellular acidification induces CTGF (show CTGF ELISA Kits) production through the OGR1/G(q/11) protein and inositol-1,4,5-trisphosphate-induced Ca(2 (show CA2 ELISA Kits)+) mobilization in human airway smooth muscle cells.
acidic pH-induced vascular actions of aortic smooth muscle cells can be dissected to OGR1-dependent and -independent pathways: COX-2 (show COX2 ELISA Kits) expression, PGI(2 (show PTGIR ELISA Kits)) production, and MKP-1 (show DUSP1 ELISA Kits) expression are mediated by OGR1, but PAI-1 (show SERPINE1 ELISA Kits) expression is not.
ovarian cancer G-protein-coupled receptor 1 (OGR1), previously described as a receptor for sphingosylphosphorylcholine, acts as a proton-sensing receptor stimulating inositol phosphate formation
OGR1 was found to evoke strong pH-dependent responses as measured by inositol phosphate accumulation.
Here, we demonstrate that metals, Fe, Zn, Co, Ni and Mn are the novel OGR1 agonists, which can singly activate OGR1 in neutral pH.
CaSR (show CASR ELISA Kits) and OGR1 reciprocally inhibit signaling through each other in central neurons, and that this is lost in their transformed counterparts. Acidification potentiates OGR1.
acidic pH stimulates cGMP accumulation preferentially through the OGR1/Gq/11 proteins/phospholipase C (show PLC ELISA Kits)/Ca(2 (show CA2 ELISA Kits)+)/nNOS (show NOS1 ELISA Kits) in N1E-115 neuronal cells. Akt (show AKT1 ELISA Kits)-mediated phosphorylation of nNOS (show NOS1 ELISA Kits)
OGR1 on dendritic cells is critical for their migration to draining lymph nodes, which, in turn, stimulates Th2 phenotype change and subsequent induction of airway inflammation and hyperreactivity.
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin (show INS ELISA Kits) secretion.
OGR1 alters the pH-sensitive response of NHE and H+-ATPase (show ATP6AP1 ELISA Kits) activity in proximal tubules.
regulator of G-protein signaling 18 (show RGS18 ELISA Kits) acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT (show NFATC1 ELISA Kits) signaling pathway
OGR1 induces an increase in Ca(i (show CA1 ELISA Kits)) in response to acidic medium and is a prime candidate for an osteoblast proton sensor.
OGR1's role in osteoclastogenesis is not strong enough to affect overall bone development.
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Function also as a metastasis suppressor gene in prostate cancer (By similarity).
G protein-coupled receptor 68
, ovarian cancer G-protein coupled receptor 1-like
, G-protein coupled receptor 68
, ovarian cancer G protein-coupled receptor, 1
, ovarian cancer G-protein coupled receptor 1
, sphingosylphosphorylcholine receptor
, g protein-coupled receptor RGR1