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The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. Additionally we are shipping G Protein-Coupled Receptor 77 Antibodies (92) and and many more products for this protein.
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C5AR (show C5AR1 ELISA Kits) and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
this study reveals a novel role for C5aR2 in C5a-mediated activation of mast cells and demonstrates that C5aR2 ligation initiates a beta (show SUCLA2 ELISA Kits)-arrestin-2 (show ARRB2 ELISA Kits)-, PI3K (show PIK3CA ELISA Kits)-, and ERK (show EPHB2 ELISA Kits)-dependent signaling pathway in these cells.
C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment.
prominent C5L2 expression in advanced atherosclerotic stages directly correlates with high levels of proinflammatory cytokines
The present study has extended the mutation spectrum of C5L2, and Thr196Asn mutations in C5L2 were associated with retinitis pigmentosa and serum lipid levels.
C5aR (show C5AR1 ELISA Kits) and C5L2 may have roles in adiposity in women
A novel polymorphism (901G > a) of C5L2 gene is associated with coronary artery disease in Chinese Han and Uyghur population.
our study indicates that 698C>T polymorphism of C5L2 gene is associated with the T2DM in individuals of Saudi population which was found to be similar with other studies.
C5L2 may be implicated in the pro-inflammatory role in C5a-primed neutrophils for ANCA-induced activation.
C5L2 receptors are abundant in neurofibrillary tangles in Alzheimer's disease brain compared to controls.
Findings demonstrate that, under excitotoxicity, Fosb (show FOSB ELISA Kits) products contribute to a neuroinflammatory response in the hippocampus through regulation of microglial C5ar1 (show C5AR1 ELISA Kits) and C5ar2 expression
This work reveals an essential role for C5L2 in C5a-triggered, AP2 (show TFAP2A ELISA Kits)-dependent C5aR (show C5AR1 ELISA Kits) internalization and downstream ERK (show EPHB2 ELISA Kits) signaling.
Mouse susceptibility to MHV-3-induced fulminant hepatitis may rely on C5a/C5aR interactions, for which ERK1/2 (show MAPK1/3 ELISA Kits) and p38 (show CRK ELISA Kits) pathways participate in up-regulating Fgl2 (show FGL2 ELISA Kits) expression.
These observations indicate the importance of C5aR (show C5AR1 ELISA Kits) in adipose tissue metabolism and immunity, which may be regulated through heterodimerization with C5L2.
in allergic contact sensitivity, as in isolated human neutrophils, C5L2 functions to suppress C5a-C5aR-mediated responses, further underscoring its role as a negative regulator of anaphylatoxin activity.
Disruption of C5L2 increases macrophage presence in white adipose tissue, contributing to obesity-associated pathologies.
C5L2 is a functional receptor for ASP (show C3 ELISA Kits) and act as a decoy receptor for C5a in pathophysiological conditions.
These findings elucidate the functional characteristics of the C5L2 receptor during the acute inflammatory response.
The results suggest that insulin (show INS ELISA Kits) sensitivity may be permissive for coupling of C5L2 levels to lipid storage and utilization.
genetic deficiency enhances the development of diet-induced insulin (show INS ELISA Kits) resistance
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants.
G protein-coupled receptor 77
, G protein-coupled receptor C5L2
, C5a anaphylatoxin chemotactic receptor 2
, C5a anaphylatoxin chemotactic receptor C5L2
, G-protein coupled receptor 77
, C5A receptor beta
, complement 5A receptor beta