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GRK5 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Additionally we are shipping G Protein-Coupled Receptor Kinase 5 Antibodies (104) and G Protein-Coupled Receptor Kinase 5 Proteins (11) and many more products for this protein.
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GRK2 (show ADRBK1 ELISA Kits) and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP5 ELISA Kits) during Wnt (show WNT2 ELISA Kits) signaling.
Suggest a common regulatory pattern for the beta(1)-AR/GRK5 which is independent of cellular type or pathology.
We demonstrated that the SNPs and the related haplotypes of GRK5 could play a central role in predisposing Parkinson disease patients to cognitive impairment.
Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (show NMUR1 ELISA Kits) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C (show CLEC2G ELISA Kits)-tail responsible for this GRK (show GRK4 ELISA Kits) function.
ADORA2A (show ADORA2A ELISA Kits) and GRK5 gene variants may influence the etiology of malaria infection.
A significant difference in the frequency of GRK5 polymorphism was found between Takotsubo cardiomyopathy patients and controls, supporting a genetic predisposition to this cardiac syndrome.
Specific patterns of altered heart GRK5 gene expression were found in models of cardiac hypertrophy.
This study sought to identify the distributed characteristics of these variant genotypes in Chinese population, and influence of GRK5 and ADRB1 (show ADRB1 ELISA Kits) polymorphisms on systolic heart failure morbidity.
GRK5 is found in a partially closed state with its kinase domain C-tail forming novel interactions with nucleotide and the N-lobe (show LTF ELISA Kits).
G protein-coupled receptor kinase 5 gene (show GPD1 ELISA Kits) polymorphisms may have a role in postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving beta-blockers
These data suggest that increased GRK5 expression may contribute to the pathophysiology of schizophrenia.
MOR (show OPRM1 ELISA Kits) phosphorylation is regulated by agonist-selective recruitment of distinct GRK (show GRK4 ELISA Kits) isoforms that influence different opioid-related behaviors. Modulation of GRK5 function could serve as a new approach for preventing addiction to opioids.
GRK5, acting in a kinase independent manner, is a facilitator of NFAT (show NFATC1 ELISA Kits) activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.
influence of GRK5 on NF-kappaB (show NFKB1 ELISA Kits) expression and activity
these data identified GRK5 as a positive regulator of insulin (show INS ELISA Kits) sensitivity.
metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2 (show ARRB2 ELISA Kits)-dependent pathway, and induces cardiac fibrosis.
These results define myocyte GRK5 as a critical regulator of pathological cardiac growth after ventricular pressure overload, supporting its role as an endogenous (patho)-physiological HDAC (show HDAC3 ELISA Kits) kinase.
these results suggest that GRK5 is an important regulator of adipogenesis and is crucial for the development of diet-induced obesity.
GRK5 regulates IL-12p40 and G-CSF (show CSF3 ELISA Kits) via a mechanism that is common to both MyD88 (show MYD88 ELISA Kits) and TRIF (show RNF138 ELISA Kits).
G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.
GRK5 is a positive regulator of TLR4 (show TLR4 ELISA Kits)-induced IkappaBalpha (show NFKBIA ELISA Kits)-NFkappaB pathway as well as a key modulator of LPS (show TLR4 ELISA Kits)-induced inflammatory response.
potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
G protein-coupled receptor kinase 5
, g protein-coupled receptor kinase GRK5