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G Protein-Coupled Receptor Kinase 5 Proteins (GRK5)

GRK5 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Additionally we are shipping G Protein-Coupled Receptor Kinase 5 Antibodies (112) and G Protein-Coupled Receptor Kinase 5 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRK5 2869 P34947
GRK5 14773 Q8VEB1
GRK5 59075 Q62833
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Top G Protein-Coupled Receptor Kinase 5 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_Baculovirus infected Insect Cells Human GST tag 5 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,697.83
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Sf-9 cells Human Un-conjugated   5 μg Log in to see 3 to 4 Days
$571.07
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$952.01
Details

GRK5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced G Protein-Coupled Receptor Kinase 5 Proteins

  1. Human GRK5 Protein expressed in Baculovirus infected Insect Cells - ABIN2003471 : Thiyagarajan, Stracquatanio, Pronin, Evanko, Benovic, Wedegaertner: A predicted amphipathic helix mediates plasma membrane localization of GRK5. in The Journal of biological chemistry 2004 (PubMed)

More Proteins for G Protein-Coupled Receptor Kinase 5 (GRK5) Interaction Partners

Zebrafish G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

  1. GRK2 (show ADRBK1 Proteins) and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.

  2. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP5 Proteins) during Wnt (show WNT2 Proteins) signaling.

Human G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

  1. Suggest a common regulatory pattern for the beta(1)-AR/GRK5 which is independent of cellular type or pathology.

  2. We demonstrated that the SNPs and the related haplotypes of GRK5 could play a central role in predisposing Parkinson disease patients to cognitive impairment.

  3. Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (show NMUR1 Proteins) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C (show CLEC2G Proteins)-tail responsible for this GRK (show GRK4 Proteins) function.

  4. ADORA2A (show ADORA2A Proteins) and GRK5 gene variants may influence the etiology of malaria infection.

  5. A significant difference in the frequency of GRK5 polymorphism was found between Takotsubo cardiomyopathy patients and controls, supporting a genetic predisposition to this cardiac syndrome.

  6. Specific patterns of altered heart GRK5 gene expression were found in models of cardiac hypertrophy.

  7. This study sought to identify the distributed characteristics of these variant genotypes in Chinese population, and influence of GRK5 and ADRB1 (show ADRB1 Proteins) polymorphisms on systolic heart failure morbidity.

  8. GRK5 is found in a partially closed state with its kinase domain C-tail forming novel interactions with nucleotide and the N-lobe (show LTF Proteins).

  9. G protein-coupled receptor kinase 5 gene (show GPD1 Proteins) polymorphisms may have a role in postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving beta-blockers

  10. These data suggest that increased GRK5 expression may contribute to the pathophysiology of schizophrenia.

Mouse (Murine) G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

  1. MOR (show OPRM1 Proteins) phosphorylation is regulated by agonist-selective recruitment of distinct GRK (show GRK4 Proteins) isoforms that influence different opioid-related behaviors. Modulation of GRK5 function could serve as a new approach for preventing addiction to opioids.

  2. GRK5, acting in a kinase independent manner, is a facilitator of NFAT (show NFATC1 Proteins) activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.

  3. influence of GRK5 on NF-kappaB (show NFKB1 Proteins) expression and activity

  4. these data identified GRK5 as a positive regulator of insulin (show INS Proteins) sensitivity.

  5. metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2 (show ARRB2 Proteins)-dependent pathway, and induces cardiac fibrosis.

  6. These results define myocyte GRK5 as a critical regulator of pathological cardiac growth after ventricular pressure overload, supporting its role as an endogenous (patho)-physiological HDAC (show HDAC3 Proteins) kinase.

  7. these results suggest that GRK5 is an important regulator of adipogenesis and is crucial for the development of diet-induced obesity.

  8. GRK5 regulates IL-12p40 and G-CSF (show CSF3 Proteins) via a mechanism that is common to both MyD88 (show MYD88 Proteins) and TRIF (show RNF138 Proteins).

  9. G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.

  10. GRK5 is a positive regulator of TLR4 (show TLR4 Proteins)-induced IkappaBalpha (show NFKBIA Proteins)-NFkappaB pathway as well as a key modulator of LPS (show TLR4 Proteins)-induced inflammatory response.

Cow (Bovine) G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

  1. GRK5, acting in a kinase independent manner, is a facilitator of NFAT (show NFATC1 Proteins) activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.

  2. potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway

  3. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.

G Protein-Coupled Receptor Kinase 5 (GRK5) Protein Profile

Protein Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).

Gene names and symbols associated with GRK5

  • G protein-coupled receptor kinase 5 (GRK5)
  • G protein-coupled receptor kinase 5 (grk5)
  • G protein-coupled receptor kinase 4 (grk4)
  • G protein-coupled receptor kinase 5 (Grk5)
  • DKFZp468J1119 protein
  • Gprk5 protein
  • GRK5 protein
  • si:dkey-171l20.1 protein
  • zgc:153020 protein

Protein level used designations for GRK5

G protein-coupled receptor kinase 5 , GRK5 , FP2025 , g protein-coupled receptor kinase GRK5

GENE ID SPECIES
100065919 Equus caballus
550070 Xenopus (Silurana) tropicalis
560806 Danio rerio
100171722 Pongo abelii
100593251 Nomascus leucogenys
560761 Danio rerio
2869 Homo sapiens
14773 Mus musculus
59075 Rattus norvegicus
281801 Bos taurus
423929 Gallus gallus
486915 Canis lupus familiaris
100152937 Sus scrofa
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