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G Protein-Coupled Receptor Kinase 6 Proteins (GRK6)

GRK6 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Additionally we are shipping G Protein-Coupled Receptor Kinase 6 Antibodies (73) and G Protein-Coupled Receptor Kinase 6 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRK6 2870 P43250
GRK6 26385 O70293
GRK6 59076  
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Top G Protein-Coupled Receptor Kinase 6 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,653.83
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GRK6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced G Protein-Coupled Receptor Kinase 6 Proteins

  1. Human GRK6 Protein expressed in Baculovirus infected Insect Cells - ABIN2004756 : Ghadessy, Willets, Kelly: G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells. in British journal of pharmacology 2003 (PubMed)
    Show all 3 references for ABIN2004756

More Proteins for G Protein-Coupled Receptor Kinase 6 (GRK6) Interaction Partners

Human G Protein-Coupled Receptor Kinase 6 (GRK6) interaction partners

  1. The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene.

  2. Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese

  3. these results indicate that GRK6 complexes with AGS3 (show GPSM1 Proteins)-Galphai2 (show GNAI2 Proteins) to regulate CXCR2 (show CXCR2 Proteins)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.

  4. GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4.

  5. results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma

  6. Downregulation of GRK6 expression enhances CXCR4 (show CXCR4 Proteins) signaling and promoted medulloblastoma cell migration.

  7. A reduced cortical concentration of GRK6 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.

  8. inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.

  9. A number of double mutations of GRK6 kinase within helices 3, 9, and 10 reduced phosphorylation of the beta2 adrenergic receptor (show ADRB2 Proteins) and rhodopsin compared to wild-type GRK6 kinase.

  10. Recruitment of beta-Arrestin 2 (show ARRB2 Proteins), but not beta-Arrestin 1 (show ARRB1 Proteins), to the active WHIM (show CXCR4 Proteins)-mutant receptor is delayed compared to the WT CXCR4 (show CXCR4 Proteins) receptor and Grk6 fails to associate with the WHIM (show CXCR4 Proteins)-mutant receptor.

Mouse (Murine) G Protein-Coupled Receptor Kinase 6 (GRK6) interaction partners

  1. GRK6 directly phosphorylates Nfkbia (show NFKBIA Proteins) at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha (show TNF Proteins)-induced NF-kappaappaB signaling.

  2. these results indicate that GRK6 complexes with AGS3 (show GPSM1 Proteins)-Galphai2 (show GNAI2 Proteins) to regulate CXCR2 (show CXCR2 Proteins)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.

  3. data demonstrate that GRK6 plays a feedback regulatory role in CXCR2 (show CXCR2 Proteins)-mediated tumor development, invasion and metastasis

  4. G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance.

  5. Chemokine receptor CXCR2 (show CXCR2 Proteins) interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis.

  6. Results identify GRK5 (show GRK5 Proteins)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP6 Proteins) during Wnt (show WNT2 Proteins) signaling.

  7. Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity.

  8. In the absence of GRK6, the G-CSF (show CSF3 Proteins)-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF (show CSF3 Proteins), significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice.

  9. The results suggest that mouse G-protein-coupled receptor (show GPR34 Proteins) kinase isoform 6-C may be considered a basic, prototypic representative of the GRK4 (show GRK4 Proteins)-like kinases.

  10. These results demonstrate previously unknown crucial regulatory mechanisms that alter ARR/GRK expression levels in macrophages that might modify many, if not all, GPCR-mediated innate immune responses.

G Protein-Coupled Receptor Kinase 6 (GRK6) Protein Profile

Protein Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with GRK6

  • G protein-coupled receptor kinase 6 (GRK6)
  • G protein-coupled receptor kinase 6 (grk6)
  • G protein-coupled receptor kinase 6 (Grk6)
  • Gprk6 protein
  • GRK6 protein
  • MGC83187 protein

Protein level used designations for GRK6

G protein-coupled receptor kinase 6 , G protein-coupled receptor kinase 6-like , g protein-coupled receptor kinase GRK6 , G-protein coupled receptor kinase 6

GENE ID SPECIES
416361 Gallus gallus
447337 Xenopus laevis
700000 Macaca mulatta
100379796 Xenopus (Silurana) tropicalis
100403264 Callithrix jacchus
100433745 Pongo abelii
100550765 Meleagris gallopavo
2870 Homo sapiens
26385 Mus musculus
59076 Rattus norvegicus
100684653 Canis lupus familiaris
521413 Bos taurus
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