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GRK6 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Additionally we are shipping G Protein-Coupled Receptor Kinase 6 Antibodies (73) and G Protein-Coupled Receptor Kinase 6 Kits (2) and many more products for this protein.
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Human GRK6 Protein expressed in Baculovirus infected Insect Cells - ABIN2004756
Ghadessy, Willets, Kelly: G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells. in British journal of pharmacology 2003
Show all 3 references for ABIN2004756
The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene.
Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese
these results indicate that GRK6 complexes with AGS3 (show GPSM1 Proteins)-Galphai2 (show GNAI2 Proteins) to regulate CXCR2 (show CXCR2 Proteins)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.
GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4.
results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma
Downregulation of GRK6 expression enhances CXCR4 (show CXCR4 Proteins) signaling and promoted medulloblastoma cell migration.
A reduced cortical concentration of GRK6 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.
inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.
A number of double mutations of GRK6 kinase within helices 3, 9, and 10 reduced phosphorylation of the beta2 adrenergic receptor (show ADRB2 Proteins) and rhodopsin compared to wild-type GRK6 kinase.
Recruitment of beta-Arrestin 2 (show ARRB2 Proteins), but not beta-Arrestin 1 (show ARRB1 Proteins), to the active WHIM (show CXCR4 Proteins)-mutant receptor is delayed compared to the WT CXCR4 (show CXCR4 Proteins) receptor and Grk6 fails to associate with the WHIM (show CXCR4 Proteins)-mutant receptor.
GRK6 directly phosphorylates Nfkbia (show NFKBIA Proteins) at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha (show TNF Proteins)-induced NF-kappaappaB signaling.
data demonstrate that GRK6 plays a feedback regulatory role in CXCR2 (show CXCR2 Proteins)-mediated tumor development, invasion and metastasis
G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance.
Chemokine receptor CXCR2 (show CXCR2 Proteins) interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis.
Results identify GRK5 (show GRK5 Proteins)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP6 Proteins) during Wnt (show WNT2 Proteins) signaling.
Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity.
In the absence of GRK6, the G-CSF (show CSF3 Proteins)-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF (show CSF3 Proteins), significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice.
The results suggest that mouse G-protein-coupled receptor (show GPR34 Proteins) kinase isoform 6-C may be considered a basic, prototypic representative of the GRK4 (show GRK4 Proteins)-like kinases.
These results demonstrate previously unknown crucial regulatory mechanisms that alter ARR/GRK expression levels in macrophages that might modify many, if not all, GPCR-mediated innate immune responses.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
G protein-coupled receptor kinase 6
, G protein-coupled receptor kinase 6-like
, g protein-coupled receptor kinase GRK6
, G-protein coupled receptor kinase 6