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GIT2 encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Additionally we are shipping GIT2 Kits (6) and GIT2 Proteins (5) and many more products for this protein.
Showing 10 out of 67 products:
Human Monoclonal GIT2 Primary Antibody for IF, WB - ABIN393670
Aslan, Baker, Loren, Haley, Itakura, Pang, Greenberg, David, Manser, Chernoff, McCarty: The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. in American journal of physiology. Cell physiology 2013
The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development.
GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.
ADMA and L-arginine (show GATM Antibodies) are substrates of human CAT2A, CAT2B, OCT2 and MATE1 (show SLC47A1 Antibodies). Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine (show GATM Antibodies)
Zeb1 (show ZEB1 Antibodies) is regulated by the Arf GTPase-activating protein (show AGAP4 Antibodies) (GAP) Git2.
GIT2 protein is tightly associated with PIX (show ARHGEF7 Antibodies) family Rac1/Cdc42 (show CDC42 Antibodies) guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules.
The expression level of lymphocyte GRK (show GRK4 Antibodies) might show the severity of CHF, and ACEI treatment could reduce the level of GRK (show GRK4 Antibodies) in CHF patients.
GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1, they participate in receptor internalization by regulating membrane trafficking between
These results suggest that inactivation of GIT2 function is a required step for induction of cell motility and that GIT2 may be a target of oncogenic signaling pathways that regulate cell migration.
Git2-short, weakly interacting with paxillin (show PXN Antibodies), functions in the regulation of Golgi organization, actin cytoskeletal organization, and subcellular localization of paxillin (show PXN Antibodies), important in integrin-mediated cell adhesion and intracellular signaling.
GIT2 is an essential terminator of TLR signaling and loss of GIT2 leads to uncontrolled inflammation and severe organ damage
these findings underscore the importance of the cytoskeleton in both osteoblast and osteoclast function and demonstrate that GIT2 plays essential roles in skeletal metabolism, affecting both bone formation and bone resorption in vivo.
GIT2 has a key role in regulating the chemokine (show CCL1 Antibodies)-mediated motility of double-positive thymocytes
Results suggest that paxillin (show PXN Antibodies)-kinase-linker is an integral component of growth factor and cell adhesion cross-talk signaling, controlling the development of front-rear cell polarity and directional cell migration.
GIT2 links chemotaxis and superoxide production in neutrophils.Loss of GIT2 in vivo leads to an immunodeficient state.
Analysis of endogenous GIT expression revealed a nearly ubiquitous distribution of GIT2, whereas GIT1 is restricted to specific cell types even in tissues with apparently high GIT1 expression and is entirely absent from some tissues.
Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
ARF GTPase-activating protein GIT2
, G protein-coupled receptor kinase-interactor 2
, G protein-coupled receptor kinase interactor 2
, ARF GAP GIT2
, GRK-interacting protein 2
, cool-associated, tyrosine phosphorylated protein 2
, cool-interacting tyrosine-phosphorylated protein 2
, ARF GTPase activating protein 2
, cool associated tyrosine phosphorylated-2
, cationic amino acid transporter-2A
, low affinity cationic amino acid transporter 2
, solute carrier family 7, member 2