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G Protein-Coupled Receptor Kinase Interactor 2 Proteins (GIT2)

GIT2 encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Additionally we are shipping GIT2 Antibodies (67) and GIT2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GIT2 9815 Q14161
Rat GIT2 GIT2 304546  
GIT2 26431 Q9JLQ2
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Top GIT2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

GIT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for G Protein-Coupled Receptor Kinase Interactor 2 (GIT2) Interaction Partners

Zebrafish G Protein-Coupled Receptor Kinase Interactor 2 (GIT2) interaction partners

  1. The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development.

Human G Protein-Coupled Receptor Kinase Interactor 2 (GIT2) interaction partners

  1. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.

  2. ADMA and L-arginine (show GATM Proteins) are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine (show GATM Proteins)

  3. Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2.

  4. GIT2 protein is tightly associated with PIX (show ARHGEF7 Proteins) family Rac1/Cdc42 (show CDC42 Proteins) guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules.

  5. The expression level of lymphocyte GRK (show GRK4 Proteins) might show the severity of CHF, and ACEI treatment could reduce the level of GRK (show GRK4 Proteins) in CHF patients.

  6. GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1, they participate in receptor internalization by regulating membrane trafficking between

  7. These results suggest that inactivation of GIT2 function is a required step for induction of cell motility and that GIT2 may be a target of oncogenic signaling pathways that regulate cell migration.

  8. Git2-short, weakly interacting with paxillin (show PXN Proteins), functions in the regulation of Golgi organization, actin cytoskeletal organization, and subcellular localization of paxillin (show PXN Proteins), important in integrin-mediated cell adhesion and intracellular signaling.

Mouse (Murine) G Protein-Coupled Receptor Kinase Interactor 2 (GIT2) interaction partners

  1. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.

  2. GIT2 is an essential terminator of TLR signaling and loss of GIT2 leads to uncontrolled inflammation and severe organ damage

  3. these findings underscore the importance of the cytoskeleton in both osteoblast and osteoclast function and demonstrate that GIT2 plays essential roles in skeletal metabolism, affecting both bone formation and bone resorption in vivo.

  4. GIT2 has a key role in regulating the chemokine (show CCL1 Proteins)-mediated motility of double-positive thymocytes

  5. Results suggest that paxillin (show PXN Proteins)-kinase-linker is an integral component of growth factor and cell adhesion cross-talk signaling, controlling the development of front-rear cell polarity and directional cell migration.

  6. GIT2 links chemotaxis and superoxide production in neutrophils.Loss of GIT2 in vivo leads to an immunodeficient state.

  7. Analysis of endogenous GIT expression revealed a nearly ubiquitous distribution of GIT2, whereas GIT1 is restricted to specific cell types even in tissues with apparently high GIT1 expression and is entirely absent from some tissues.

  8. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.

GIT2 Protein Profile

Protein Summary

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.

Gene names and symbols associated with GIT2

  • G protein-coupled receptor kinase interactor 2 (GIT2)
  • G protein-coupled receptor kinase interacting ArfGAP 2 (GIT2)
  • G protein-coupled receptor kinase interacting ArfGAP 2 (git2)
  • G protein-coupled receptor kinase interactor 2a (git2a)
  • G protein-coupled receptor kinase interacting ArfGAP 2 (Git2)
  • G protein-coupled receptor kinase-interactor 2 (Git2)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (Slc7a2)
  • 1500036H07Rik protein
  • 5830420E16Rik protein
  • 6430510B20Rik protein
  • 9630056M03Rik protein
  • B230104M05Rik protein
  • CAT-2 protein
  • Cat2 protein
  • Cat2a protein
  • Cat2b protein
  • git2 protein
  • mKIAA0148 protein
  • RCAT2 protein
  • si:dkey-234h16.4 protein
  • xgit2 protein

Protein level used designations for GIT2

ARF GTPase-activating protein GIT2 , G protein-coupled receptor kinase-interactor 2 , G protein-coupled receptor kinase interactor 2 , ARF GAP GIT2 , GRK-interacting protein 2 , cool-associated, tyrosine phosphorylated protein 2 , cool-interacting tyrosine-phosphorylated protein 2 , ARF GTPase activating protein 2 , cool associated tyrosine phosphorylated-2 , CAT-2 , cationic amino acid transporter-2A , low affinity cationic amino acid transporter 2 , solute carrier family 7, member 2

GENE ID SPECIES
374035 Gallus gallus
452227 Pan troglodytes
477520 Canis lupus familiaris
549671 Xenopus (Silurana) tropicalis
793882 Danio rerio
100066470 Equus caballus
9815 Homo sapiens
304546 Rattus norvegicus
516048 Bos taurus
26431 Mus musculus
64554 Rattus norvegicus
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