G Protein-Coupled Receptor 17 Proteins (GPR17)

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Additionally we are shipping GPR17 Antibodies (97) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPR17 2840 Q13304
GPR17 574402 Q6NS65
Rat GPR17 GPR17 767613 Q09QM4
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Top GPR17 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 11 to 12 Days
$491.43
Details

GPR17 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for G Protein-Coupled Receptor 17 (GPR17) Interaction Partners

Human G Protein-Coupled Receptor 17 (GPR17) interaction partners

  1. uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds.

  2. GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

  3. This review summarizes knowledge about role of GPR17 receptors in physiology and pathology of nervous system, with special attention to remyelination processes.

  4. Low levels of GRK2 (show ADRBK1 Proteins)/GRK5 (show GRK5 Proteins) causes a slow and not complete desensitization/down-regulation of GPR17.

  5. Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor (show GPRC5D Proteins) GPR17.

  6. Data validate GPR17 as a target for neurorepair

  7. Nucleotides, nucleotide sugars, and cysteinyl leukotrienes do not promote activation of GPR17 in five different cell lines, nor does GPR17 have signaling properties.

  8. analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells

  9. A functional cross-talk exists between cysteinyl-leukotriene and purinergic sites at GPR17; the latter have a hierarchy in producing desensitizing signals.

  10. We present the first isoform-specific characterization of GPR17 and show that differences exist between the isoforms in expression pattern and pharmacological profile; the two human isoforms might serve tissue-specific functions

Mouse (Murine) G Protein-Coupled Receptor 17 (GPR17) interaction partners

  1. The loss of Gpr17 in mice led to precocious myelination and an earlier onset of remyelination after demyelination

  2. uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds.

  3. GPR17(+) cells--in contrast to GPR17(-) NG2 (show Vcan Proteins)-glia--did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia

  4. stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (show MBP Proteins) expression levels mainly by triggering the Galphai/o signaling pathway.

  5. Agrp (show AGRP Proteins)-Gpr17(-/-) mice show reduced food intake, increased relative energy expenditure, and increased satiety, resulting in leanness and reduced body fat. They also show increased central nervous system sensitivity to insulin (show INS Proteins) and leptin (show LEP Proteins).

  6. The mouse GPR17 receptor plays a central role in the early response of cardiac stromal cells to ischaemia.

  7. Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor (show GPRC5C Proteins) GPR17.

  8. GPR17 is a marker for progenitor progression within the oligodendroglial lineage that participates in postacute reactivity of NG2 (show Vcan Proteins)-proteoglycan (show Vcan Proteins) expressing cells in different injury paradigms.

  9. CysLT1R (show CYSLTR1 Proteins), CysLT2R (show CYSLTR2 Proteins) and GPR17 might be involved in the MPTP (show PTPN2 Proteins)-induced Parkinson disease damage in mice.

  10. analysis of agonist-induced trafficking of native GPR17 in oligodendroglial cells

GPR17 Protein Profile

Protein Summary

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene names and symbols associated with GPR17

  • G protein-coupled receptor 17 (GPR17)
  • G protein-coupled receptor 17 (Gpr17)
  • AI853548 protein
  • GPR17 protein

Protein level used designations for GPR17

G protein-coupled receptor 17 , uracil nucleotide/cysteinyl leukotriene receptor-like , uracil nucleotide/cysteinyl leukotriene receptor , G-protein coupled receptor 17 , P2Y-like receptor , R12 , UDP/CysLT receptor

GENE ID SPECIES
699576 Macaca mulatta
769024 Gallus gallus
100444185 Pongo abelii
100593986 Nomascus leucogenys
100611956 Pan troglodytes
782442 Bos taurus
2840 Homo sapiens
574402 Mus musculus
767613 Rattus norvegicus
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