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High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). Additionally we are shipping GPR31 Antibodies (22) and many more products for this protein.
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Suggest that GPR31 acts as a secretory pathway chaperone for KRAS4B in tumor cells.
The data implicate 12-HETER1 in a critical new role in the regulation of prostate cancer progression and offer a novel alternative target for therapeutic intervention.
12-HETER represents the first identified high affinity receptor for the 12-(S)-HETE hydroxyl fatty acids.
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B (By similarity).
G protein-coupled receptor 31
, 12-(S)-HETE acid receptor
, 12-(S)-HETE receptor
, 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor
, 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
, G-protein coupled receptor 31
, bA517H2.2 (G protein-coupled receptor 31)
, hydroxyeicosatetraenoic (HETE) acid receptor 1
, probable G-protein coupled receptor 31