G Protein-Coupled Receptor 81 (GPR81) ELISA Kits

G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005].. Additionally we are shipping G Protein-Coupled Receptor 81 Antibodies (100) and G Protein-Coupled Receptor 81 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse GPR81 GPR81 243270  
Anti-Rat GPR81 GPR81 689936  
Anti-Human GPR81 GPR81 27198 Q9BXC0
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More ELISA Kits for G Protein-Coupled Receptor 81 Interaction Partners

Mouse (Murine) G Protein-Coupled Receptor 81 (GPR81) interaction partners

  1. lactate can induce GPR81-independent metabolic changes that modulate macrophage pro-inflammatory activation.

  2. GPR81 expression increased during gestation, and peaked near labor. GPR81 is expressed in the uterus with high expression in myometrium. GPR81 mediates inflammation in the laboring uterus.

  3. Results indicate that lactate may aggravated ischemic brain injury by activating GPR81 and inhibition of GPR81 protects against ischemia-induced cell death via an antiapoptosis pathway

  4. Description of a GPR81 selective agonist with in vivo efficacy, inhibiting lipolysis without flushing.

  5. Lactate negatively regulates TLR induction of the NLRP3 (show NLRP3 ELISA Kits) inflammasome and production of IL1beta (show IL1B ELISA Kits), via ARRB2 (show ARRB2 ELISA Kits) and GPR81 in liver and pancreatic injury.

  6. chronic obesity reduces GPR109A and GPR81 expression in the adipose tissue, while acute in vitro LPS treatment increases expression of GPR109A in adipocytes and macrophages.

  7. Inflammation decreases the expression of GPR81 in adipose tissue

  8. An autocrine lactate loop mediates insulin (show INS ELISA Kits)-dependent inhibition of lipolysis through GPR81.

  9. GPR81 couples to the Gi signaling pathway

  10. Data show that siRNA-mediated knockdown (show PPARG ELISA Kits)of PPARgamma in differentiated 3T3-L1 adipocytes showed a significant decrease in Gpr81 protein expression.

Human G Protein-Coupled Receptor 81 (GPR81) interaction partners

  1. Activation of GPR81 decreases intracellular cAMP levels and inhibits PKA activity, leading to activation of TAZ (show TAZ ELISA Kits) and upregulation of PD-L1 (show CD274 ELISA Kits). This study reveals a critical role for lactate in the immune checkpoint pathway and an unexpected function of TAZ (show TAZ ELISA Kits) in tumor evasion of the T-cell-mediated immune response.

  2. Lactate receptor/HCAR1 expression in cervical carcinoma cells may contribute to the modulation of cellular DNA repair mechanisms.

  3. HCA1/3 are necessary for breast cancer cells to balance lipid/fatty acid metabolism.

  4. HCAR1 and monocarboxylate transporters activity is required for the L- and D-lactate-mediated enhancement of DNA repair and of HeLa cell survival.

  5. Description of a GPR81 selective agonist with in vivo efficacy, inhibiting lipolysis without flushing.

  6. Data support that GPR81 is important for cancer cell regulation of lactate transport mechanisms.

  7. Lactate negatively regulates TLR induction of the NLRP3 (show NLRP3 ELISA Kits) inflammasome and production of IL1beta (show IL1B ELISA Kits), via ARRB2 (show ARRB2 ELISA Kits) and GPR81 in liver and pancreatic injury.

  8. demonstrated that the C165-E166-S167-F168 motif at the second extracellular loop is critical for GPR81 function, and the conserved six Cys (show DNAJC5 ELISA Kits) residues at the extracellular regions are necessary for GPR81 function

  9. GPR81 with relatively restricted expression in the adipose tissues functions as a receptor for lactate and can mediate an anti-lipolytic effect of lactate.

  10. Data show that the coordinated PPARgamma (show PPARG ELISA Kits)-mediated regulation of the GPR81, GPR109A and GPR109B presents a novel mechanism by which TZDs may reduce circulating free fatty acid levels and perhaps ameliorate insulin (show INS ELISA Kits) resistance in obese patients.

G Protein-Coupled Receptor 81 (GPR81) Antigen Profile

Antigen Summary

G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.

Gene names and symbols associated with GPR81

  • G protein-coupled receptor 81 (GPR81) antibody
  • hydroxycarboxylic acid receptor 1 (HCAR1) antibody
  • hydroxycarboxylic acid receptor 1-1 (hcar1-1) antibody
  • G protein-coupled receptor 81 (LOC100345808) antibody
  • G protein-coupled receptor 81 (Gpr81) antibody
  • hydroxycarboxylic acid receptor 1 (GPR81) antibody
  • GPR81 antibody
  • gpr81-1 antibody
  • GPR104 antibody
  • HCA1 antibody
  • Hcar1 antibody
  • LACR1 antibody
  • TA-GPCR antibody

Protein level used designations for GPR81

G protein-coupled receptor 81 , G-protein coupled receptor 81 , hydroxycarboxylic acid receptor 1 , G protein-coupled receptor 104 , G-protein coupled receptor 104 , T-cell activation G protein-coupled receptor , hydroxy-carboxylic acid receptor 1 , lactate receptor 1

GENE ID SPECIES
452331 Pan troglodytes
538759 Bos taurus
570755 Danio rerio
702825 Macaca mulatta
100345808 Oryctolagus cuniculus
243270 Mus musculus
689936 Rattus norvegicus
486252 Canis lupus familiaris
27198 Homo sapiens
100153287 Sus scrofa
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