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The protein encoded by Gsbs is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. Additionally we are shipping G Substrate Antibodies (19) and many more products for this protein.
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G-substrate plays a role in the NO-sGC (show SGCB Proteins)-cGMP-PKG (show PRKG1 Proteins) pathway, cerebellum-dependent long-term memory, & neuroprotection of the ventral tegmentum and retina. Review.
Single nucleotide polymorphism in the GSBS gene is associated with hypercholesterolemia
G-substrate reduces vulnerability of dopaminergic cells in models of Parkinson's disease.
The mice with targeted G-substrate gene knockout results in the impairment of cerebellum-dependent long-term memory (optokinetic response adaptation) without influence on short-term one.
retinal G-substrate plays a role as a downstream component of the NO-cGMP-PKG pathway. The co-localization of retinal G-substrate with protein Ser/Thr phosphatases suggests that it acts as an endogenous protein phosphatase inhibitor.
The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene.
, protein phosphatase 1 regulatory subunit 17
, G substrate
, protein phosphatase 1, regulatory (inhibitor) 2