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G-Protein Signaling Modulator 2 (GPSM2) ELISA Kits

The protein encoded by GPSM2 belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. Additionally we are shipping GPSM2 Antibodies (52) and GPSM2 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human GPSM2 GPSM2 29899 P81274
Anti-Rat GPSM2 GPSM2 362021  
Anti-Mouse GPSM2 GPSM2 76123 Q8VDU0
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More ELISA Kits for GPSM2 Interaction Partners

Human G-Protein Signaling Modulator 2 (GPSM2) interaction partners

  1. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  2. This study determined the crystallographic structure of human Afadin (show MLLT4 ELISA Kits) in complex with LGN.

  3. results fit a model whereby LGN influences interphase microtubule dynamics in endothelial cells to regulate migration, cell adhesion, and sprout extension, and reveal a novel non-mitotic role for LGN in sprouting angiogenesis

  4. A crystal structure of Frmpd4 (show FRMPD4 ELISA Kits)-bound LGN in an oxidized form is also reported, although oxidation does not appear to strongly affect the interaction with Frmpd4 (show FRMPD4 ELISA Kits).

  5. LGN is required for mitotic spindle rotation but not orientation maintenance.

  6. Hepatocyte Par1b (show MARK2 ELISA Kits) defines lumen position in concert with the position of the astral microtubule anchoring complex LGN-NuMA (show NUMA1 ELISA Kits) to yield the distinct epithelial division phenotypes.

  7. one homozygous frameshift GPSM2 variants c.1473delG was identified in three Chudley-McCullough syndrome Dutch patients.

  8. Data indicate that dynein- and astral microtubule-mediated transport of Galphai/LGN/nuclear mitotic apparatus (NuMA (show NUMA1 ELISA Kits)) complex from cell cortex to spindle poles.

  9. Studies indicate that the Inscuteable (Insc)and NuMA (show NUMA1 ELISA Kits) are mutually exclusive interactors of LGN.

  10. Results show compound heterozygous mutations in the GPSM2 gene, in affected members of a family with Chudley-McCullough syndrome, co-segregate in the family as an autosomal recessive trait.

Mouse (Murine) G-Protein Signaling Modulator 2 (GPSM2) interaction partners

  1. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  2. these results show a context-dependent function for LGN.

  3. support for the hitherto untested model that Par3 (show F2RL2 ELISA Kits)-mInsc and Galphai3 (show GNAI3 ELISA Kits) act cooperatively to polarize LGN and promote perpendicular divisions

  4. LGN-TPR motifs are versatile and capable of recognizing multiple targets via diverse binding modes.

  5. X-ray crystallography and binding studies reveal that LGN GoLoco binding motifs are potent guanine nucleotide dissociation inhibitors.

  6. The restricted localization of NuMA (show NUMA1 ELISA Kits) in the lateral belt is instructive for the planar alignment of the mitotic spindle, and required for its planar maintenance.

  7. Knocking out LGN, (the G protein regulator), randomized the orientation of normally planar neuroepithelial divisions.

  8. Excessive LGN induces meiotic spindle organization defects by elongating the spindle and enhancing pole focusing, whereas depletion of LGN by RNA interference results in meiotic spindle deformation and chromosome misalignment.

GPSM2 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).

Gene names and symbols associated with GPSM2

  • G-protein signaling modulator 2 (GPSM2) antibody
  • G-protein signaling modulator 2 (gpsm2) antibody
  • G-protein signaling modulator 2 (Gpsm2) antibody
  • G-protein signalling modulator 2 (AGS3-like, C. elegans) (gpsm2) antibody
  • G-protein signalling modulator 2 (AGS3-like, C. elegans) (Gpsm2) antibody
  • 6230410J09Rik antibody
  • CMCS antibody
  • dfnb82 antibody
  • lgn antibody
  • Pins antibody
  • Pinsa antibody
  • RGD1560967 antibody
  • zgc:63574 antibody

Protein level used designations for GPSM2

G-protein signalling modulator 2 (AGS3-like, C. elegans) , G-protein-signaling modulator 2 , mosaic protein LGN , G-protein signaling modulator 2 (AGS3-like, C. elegans) , G-protein signaling modulator 2 (AGS3-like) , LGN protein , pins homolog (Drosophia)

GENE ID SPECIES
100518248 Sus scrofa
29899 Homo sapiens
490127 Canis lupus familiaris
379843 Xenopus laevis
424342 Gallus gallus
513654 Bos taurus
362021 Rattus norvegicus
393410 Danio rerio
76123 Mus musculus
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