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GA Binding Protein Transcription Factor, alpha Subunit 60kDa Proteins (GABPA)

GABPA encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Additionally we are shipping GA Binding Protein Transcription Factor, alpha Subunit 60kDa Antibodies (89) and GA Binding Protein Transcription Factor, alpha Subunit 60kDa Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat GABPA GABPA 363735  
GABPA 2551 Q06546
GABPA 14390 Q00422
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Top GA Binding Protein Transcription Factor, alpha Subunit 60kDa Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

GABPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced GA Binding Protein Transcription Factor, alpha Subunit 60kDa Proteins

  1. Human GABPA Protein expressed in Wheat germ - ABIN1354635 : Makowski, Willems, Fang, Choi, Zhang, Jansen, Brown, Vermeulen: An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations. in Proteomics 2016 (PubMed)

More Proteins for GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) Interaction Partners

Human GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) interaction partners

  1. ELF1 (show EFNA2 Proteins) binding occurs at both TERT (show TERT Proteins) promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS (show ETS1 Proteins) motifs in the TERT (show TERT Proteins) promoter region.

  2. The results suggest that NRF-2alpha is a regulator of SIRT3 (show SIRT3 Proteins) expression and may shed light on how SIRT3 (show SIRT3 Proteins) is upregulated during nutrient stress.

  3. GABPalpha Binding to Overlapping ETS (show ETS1 Proteins) and CRE DNA Motifs Is Enhanced by CREB1 (show CREB1 Proteins)

  4. Expression of the ETS transcription factor (show FEV Proteins) GABPalpha is positively correlated to the BCR (show BCR Proteins)-ABL1/ABL1 (show ABL1 Proteins) ratio in CML (show BCR Proteins) patients and affects imatinib sensitivity in vitro.

  5. study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b (show ITGAM Proteins) as a novel GABP target gene

  6. GABPA thus directly links TERT (show TERT Proteins) promoter mutations to aberrant expression in multiple cancers.

  7. GABPA exhibits an increase in binding signal with higher numbers of ETS (show ETS1 Proteins) motifs per promoter. Analysis of the distance between inverted pairs of ETS (show ETS1 Proteins) motifs within promoters and binding by p53 (show TP53 Proteins), ETS1 (show ETS1 Proteins) and GABPA, shows a coordination of binding for the 3.

  8. results demonstrate the functional importance of the C/EBPalpha (show CEBPA Proteins) C-terminus beyond the bZIP DNA-binding and dimerization region, which may mediate cooperative activation by C/EBPalpha (show CEBPA Proteins) and GABP of myeloid-specific genes

  9. GABP alpha is required for YAP (show YAP1 Proteins) expression in vitro and in vivo, and that YAP (show YAP1 Proteins) is an important effector downstream of GABP for cell survival and cell-cycle progression.

  10. When NRF-2alpha and NRF-2beta form a complex, the nuclear import of NRF-2alphabeta becomes strictly dependent on the nuclear localization signal within NRF-2beta.

Mouse (Murine) GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) interaction partners

  1. GABPalpha Binding to Overlapping ETS (show ETS1 Proteins) and CRE DNA Motifs Is Enhanced by CREB1 (show CREB1 Proteins)

  2. conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression

  3. Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL (show ABL1 Proteins)-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.

  4. NRF-2 (show NFE2L2 Proteins) and NRF-1 (show NRF1 Proteins) operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.

  5. Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx (show ZFX Proteins) and Etv6 (show ETV6 Proteins) transcription factors and prosurvival Bcl-2 (show BCL2 Proteins) family members including Bcl-2 (show BCL2 Proteins), Bcl-X(L (show BCL2L1 Proteins)), and Mcl-1 (show MCL1 Proteins) as direct GABP target genes.

  6. Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.

  7. chemical shift and secondary structure of the PNT (show ETS2 Proteins)/SAM (show TTN Proteins) domains

  8. Erralpha and GA-binding protein a partner with PGC-1alpha in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes

  9. Gabpa function is essential and is not compensated for by other ETS (show ETS1 Proteins) transcription factors and is consistent with a specific requirement for Gabp expression for the maintenance of target genes involved in embryo essential mitochondrial cellular functions

  10. GABP is essential for the regulation of IL-7Ralpha (show IL7R Proteins) expression in T cells.

GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) Protein Profile

Protein Summary

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with GABPA

  • GA binding protein transcription factor, alpha subunit 60kDa (gabpa-A)
  • GA binding protein transcription factor, alpha subunit 60kDa (GABPA)
  • GA binding protein transcription factor, alpha subunit 60kDa (gabpa)
  • GA binding protein transcription factor, alpha subunit 60kDa (LOC100222977)
  • GA binding protein transcription factor, alpha subunit (Gabpa)
  • GA repeat binding protein, alpha (Gabpa)
  • GA-binding protein transcription factor, alpha subunit (gabpa)
  • e4tf protein
  • E4TF1-60 protein
  • E4TF1A protein
  • GABPA protein
  • gabpa-A protein
  • GABPalpha protein
  • NFT2 protein
  • Nrf-2alpha protein
  • NRF2 protein
  • NRF2A protein
  • RCH04A07 protein
  • wu:fc12d11 protein
  • X-alpha1 protein
  • XrpFI protein

Protein level used designations for GABPA

GA binding protein transcription factor, alpha subunit 60kDa , transcription factor GABP alpha subunit , GA binding protein transcription factor, alpha subunit (60kD) , GA-binding protein alpha chain-like , GA repeat binding protein, alpha , GA-binding protein alpha chain , nuclear respiratory factor 2 alpha , GA binding protein transcription factor alpha subunit 60kDa , GABP subunit alpha , human nuclear respiratory factor-2 subunit alpha , nuclear respiratory factor 2 alpha subunit , nuclear respiratory factor 2 subunit alpha , transcription factor E4TF1-60 , GA repeat binding protein alpha , GA-binding protein alpha-subunit , E4tf1-60 transcription factor

GENE ID SPECIES
378601 Xenopus laevis
443478 Ovis aries
474079 Pan troglodytes
100012735 Monodelphis domestica
100053853 Equus caballus
100126064 Xenopus (Silurana) tropicalis
100222977 Taeniopygia guttata
100406317 Callithrix jacchus
100438238 Pongo abelii
100466575 Ailuropoda melanoleuca
100548020 Meleagris gallopavo
100558009 Anolis carolinensis
100585028 Nomascus leucogenys
363735 Rattus norvegicus
2551 Homo sapiens
446729 Xenopus laevis
418478 Gallus gallus
478394 Canis lupus familiaris
510204 Bos taurus
14390 Mus musculus
58110 Danio rerio
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