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The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009].. Additionally we are shipping and many more products for this protein.
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Rat (Rattus) Polyclonal GAT1 Primary Antibody for ICC, IHC - ABIN1742535
Aracri, Meneghini, Coatti, Amadeo, Becchetti: α4β2(∗) nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex. in Neuroscience 2016
Dog (Canine) Polyclonal GAT1 Primary Antibody for ELISA, WB - ABIN4273530
de Krom, Staal, Ophoff, Hendriks, Buitelaar, Franke, de Jonge, Bolton, Collier, Curran, van Engeland, van Ree: A common variant in DRD3 receptor is associated with autism spectrum disorder. in Biological psychiatry 2009
the "extra" residue in transmembrane domain 10 of the GABA transporter GAT-1 provides extra bulk, probably in the form of a pi-helix, which is required for stringent gating and tight coupling of ion and substrate fluxes in the GABA transporter family.
Results show that SLC6A1 (show SLC6A1 PLURAL_@19116@) minor genotypes/alleles were protective against risk for alcoholism in 3 ethnically diverse cohorts.
Genome-wide significant associations were highly biological plausible, including associations within GABA transporter 1, SLC6A1 (show SLC6A1 Antibodies) (solute carrier (show SERTAD2 Antibodies) family 6, member 1), and exonic hits in LOC100129340 (mitofusin-1 (show MFN1 Antibodies)-like
targeted resequencing of 644 individuals with epileptic encephalopathies led to the identification of six SLC6A1 (show SLC6A1 PLURAL_@19116@) mutations in seven individuals, all of whom have epilepsy with myoclonic-atonic seizures (MAE).
3p25.3 microdeletion of GABA transporters SLC6A1 (show SLC6A1 PLURAL_@26344@) and SLC6A11 (show SLC6A11 PLURAL_@26344@) results in intellectual disability, epilepsy and stereotypic behavior.
Cysteine mutagenesis of GAT-1 pointed to conformationally sensitive proximity of extracellular loops 2 and 4 in this protein.
The aromatic and charge pairs of the thin extracellular gate of the GABA transporter GAT-1 are differently impacted by mutation.
a functional interaction of the external and internal gates of GAT-1 is essential for transport
TM10 of GAT-1 lines an accessibility pathway from the extracellular space into the binding pocket and plays a role in the opening and closing of the extracellular transporter gate.
GABA Transporter Mutagenesis Database (GATMD), a web-accessible, relational database of manually annotated biochemical, functional and pharmacological data reported on GAT1.
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009
GABA transporter 1
, sodium- and chloride-dependent GABA transporter 1
, solute carrier family 6 (neurotransmitter transporter, GABA), member 1
, solute carrier family 6 member 1
, Betaine/GABA transporter 1
, Na(+)/Cl(-) betaine/GABA transporter
, sodium- and chloride-dependent betaine transporter
, solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
, solute carrier family 6 member 12
, vesicular GABA transporter