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Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter.
3p25.3 microdeletion of GABA transporters SLC6A1 (show SLC6A1 Antibodies) and SLC6A11 (show SLC6A11 Antibodies) results in intellectual disability, epilepsy and stereotypic behavior.
Binding assays employing membrane preparations obtained from a stably GAT3 (show SLC6A11 Antibodies) expressing HEK293 cell line and DDPM-1007 as nonlabeled GAT3 (show SLC6A11 Antibodies) marker were performed. In these experiments specific binding of DDPM-1007 at GAT3 (show SLC6A11 Antibodies) could be unambiguously detected.
The results suggest that GAT3 (show SLC6A11 Antibodies) c.1572T may be one of the contributing factors with a modest effect on antiepileptic drug (AEDs) pharmacoresistance in the epileptic brain.
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters, such as SLC6A11 (Borden et al., 1994
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
, GABA transporter 3
, sodium- and chloride-dependent GABA transporter 3
, solute carrier family 6 member 11