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Transcriptional activator which probably serves as a general switch factor for erythroid development. Additionally we are shipping GATA1 Kits (20) and GATA1 Antibodies (6) and many more products for this protein.
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deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta (show TGFB1 Proteins) content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen.
findings suggest that Gata1 & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
GATA1 and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (show RPS19 Proteins) gene which is frequently mutated in Diamond-Blackfan Anemia.
TAL1 (show TAL1 Proteins) and GATA1 form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations
We propose that the CID (show CENPA Proteins)-dependent dimerization system combined with the EpoR (show EPOR Proteins) intracellular domain and the Gata1 gene regulatory region generates a novel peroral strategy for the treatment of anemia.
immunoprecipitation. Our data provide new insights into the expanded regulatory circuitry that coordinates Nanog expression.
Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1 (show ZGLP1 Proteins).
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells
By ablating TAF10 (show TAF10 Proteins) specifically in erythroid cells in vivo, observed is a differentiation block accompanied by deregulated GATA1 target genes, including Gata1 itself, suggesting functional cross talk between GATA1 and TAF10 (show TAF10 Proteins).
GATA-1 deficiency can partially rescue the trabecular bone loss observed with osteoprotegerin (show TNFRSF11B Proteins) deficiency
Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence within regulatory regions of globin genes and of other genes expressed in erythroid cells.
GATA-binding factor 1
, GATA-binding protein 1
, NF-E1 DNA-binding protein
, erythroid transcription factor
, GATA-binding protein 1 (globin transcription factor 1)